Impact of cadmium toxicity on cartilage loss in a 3D in vitro model
Por:
Yessica Eduviges Z.-C., Martinez-Nava, Gabriela, Reyes-Hinojosa, Daniel, Mendoza-Soto, Luzia, Fernandez-Torres, Javier, Lopez-Reyes, Alberto, Olivos-Meza, Anell, Armienta-Hernández M.A., Ruíz-Huerta E.A., de Jesus Gonzalez-Guadarrama, Maria, Sandoval B.V., Landa-Solis, Carlos, Sanchez-Sanchez, Roberto, Suarez-Ahedo, Carlos, Lozada-Pérez C.A., Gutiérrez-Ruiz M.C., Clavijo-Cornejo, Denise, Pineda, Carlos, Jacobo-Albavera, Leonor, Dominguez-Perez, Mayra, Martinez-Flores, Karina
Publicada:
1 ene 2020
Resumen:
Osteoarthritis (OA) is the gradual loss of articular cartilage and decrease in subchondral space. One of the risk factors Exposure to cadmium (Cd) through tobacco smoke has been identified as a major OA risk factor. There are no reports addressing the role of Cd in OA progression at the molecular level. Our findings revealed that Cd can promote the activation of metalloproteinases (MMP1, MMP3, MMP9 y MMP13), affecting the expression of COL2A1 and ACAN, and decreasing the presence of glycosaminoglycans and proteoglycans through an inflammatory response related to IL-1ß y a IL-6, as well as oxidative by producing ROS like O2 -• and H2O2. In conclusion, our findings suggest a cytotoxic role of Cd in the articular cartilage, which could affect OA development. © 2019 Elsevier B.V.
Filiaciones:
Yessica Eduviges Z.-C.:
Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Martinez-Nava, Gabriela:
Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Synovial Fluid, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Reyes-Hinojosa, Daniel:
Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Synovial Fluid, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Mendoza-Soto, Luzia:
Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Synovial Fluid, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Fernandez-Torres, Javier:
Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Synovial Fluid, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Lopez-Reyes, Alberto:
Gerosciences, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Gerosci, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Olivos-Meza, Anell:
Orthopedic Sports Medicine and Arthroscopy Service, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Orthoped Sports Med & Arthroscopy Serv, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Armienta-Hernández M.A.:
Departament of Natural Resources, Institute of Geophysics, UNAM. Circuito de la investigación Científica s/n, Ciudad Universitaria, Cd. Universitaria, Mexico City, C.P. 04150, Mexico
Ruíz-Huerta E.A.:
Departament of Natural Resources, Institute of Geophysics, UNAM. Circuito de la investigación Científica s/n, Ciudad Universitaria, Cd. Universitaria, Mexico City, C.P. 04150, Mexico
de Jesus Gonzalez-Guadarrama, Maria:
Departament of Natural Resources, Institute of Geophysics, UNAM. Circuito de la investigación Científica s/n, Ciudad Universitaria, Cd. Universitaria, Mexico City, C.P. 04150, Mexico
Univ Nacl Autonoma Mexico, Inst Geophys, Dept Nat Resources, Circuito Invest Cient S-N,Ciudad Univ, Mexico City 04150, DF, Mexico
Sandoval B.V.:
Microscopy Laboratory, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Landa-Solis, Carlos:
Tissue Engineering and Cell Therapy and Regenerative Medicine Unit, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Tissue Engn & Cell Therapy & Regenerat Med Unit, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Sanchez-Sanchez, Roberto:
Tissue Engineering and Cell Therapy and Regenerative Medicine Unit, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Tissue Engn & Cell Therapy & Regenerat Med Unit, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Suarez-Ahedo, Carlos:
Departament of Adult Joint Reconstruction, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Dept Adult Joint Reconstruct, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Lozada-Pérez C.A.:
Rheumatology Service, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Gutiérrez-Ruiz M.C.:
Department of Health Sciences, Autonomous Metropolitan University, Laboratory of Experimental Medicine, Unit of Translational Medicine, Institute of Biomedical Research, UNAM, National Institute of Cardiology “Ignacio Chávez”, Mexico City, Mexico
Clavijo-Cornejo, Denise:
Division of Musculoskeletal and Rheumatic Disorders, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, Mexico City, C.P. 14389, Mexico
Natl Inst Rehabil, Div Musculoskeletal & Rheumat Disorders, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Pineda, Carlos:
Division of Musculoskeletal and Rheumatic Disorders, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, Mexico City, C.P. 14389, Mexico
Natl Inst Rehabil, Div Musculoskeletal & Rheumat Disorders, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Jacobo-Albavera, Leonor:
Genomics of Cardiovascular Diseases Laboratory, National Institute of Genomic Medicine, Periférico Sur 4809, Col. Arenal TepepanC.P. 14610, Mexico
Natl Inst Genom Med, Genom Cardiovasc Dis Lab, Periferico 4809, Mexico City 14610, DF, Mexico
Dominguez-Perez, Mayra:
Genomics of Cardiovascular Diseases Laboratory, National Institute of Genomic Medicine, Periférico Sur 4809, Col. Arenal TepepanC.P. 14610, Mexico
Natl Inst Genom Med, Genom Cardiovasc Dis Lab, Periferico 4809, Mexico City 14610, DF, Mexico
Martinez-Flores, Karina:
Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de GuadalupeC.P. 14389, Mexico
Natl Inst Rehabil, Synovial Fluid, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Natl Inst Rehabil, Microscopy Lab, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Natl Inst Rehabil, Rheumatol Serv, Calzada Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Univ Nacl Autonoma Mexico, Autonomous Metropolitan Univ, Natl Inst Cardiol Ignacio Chavez,Inst Biomed Res, Dept Hlth Sci,Lab Expt Med,Unit Translat Med, Mexico City, DF, Mexico
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