Gestational exposure to the cannabinoid WIN 55,212-2 and its effect on the innate intestinal immune response
Por:
Hernandez-Cervantes, Rosalia, Perez-Torres, Armando, Prospero-Garcia, Oscar, Morales Montor, Jorge
Publicada:
1 ene 2019
Categoría:
Multidisciplinary
Resumen:
The consequences of marijuana consumption during pregnancy and its effects on the function of the immune system have been little studied. Marijuana is one of the most consumed recreational drugs among pregnant women, and it is known that gestational exposure to marijuana can have serious effects on the offspring after birth. In this study, we challenged the immune system of Wistar rats by infecting them with the parasitic nematode Trichinella spiralis. A treatment group of these animals was prenatally exposed to the cannabinoid WIN 55,212-2; a control group was not exposed. At 5 days of infection, the treated animals were less effective in eliminating intestinal parasites; moreover, this effect was correlated with a deficiency in mucus production, lower recruitment of eosinophils in the duodenum, and a reduced percentage of T?d and NK cells. In conclusion, the gestational administration of the synthetic cannabinoid WIN 55,212-2 induces lasting changes to the function of the immune system against infection with T. spiralis in male Wistar rats, making them more susceptible to infection. © 2019, The Author(s).
Filiaciones:
Hernandez-Cervantes, Rosalia:
Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City, DF, Mexico
Perez-Torres, Armando:
Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City, DF, Mexico
Prospero-Garcia, Oscar:
Grupo de Neurociencias, Laboratorio de Cannabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Grp Neurociencias,Lab Cannabinoides, Mexico City, DF, Mexico
Morales Montor, Jorge:
Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City, DF, Mexico
|