Association of TRAF1/C5 Locus Polymorphisms with Epilepsy and Clinical Traits in Mexican Patients with Neurocysticercosis
Por:
Villegas, Marcela, Sciutto, Edda, Rosetti, Marcos, Fleury, Agnes, Fragoso, Gladis
Publicada:
1 ene 2019
Resumen:
Neurocysticercosis is caused by the establishment of Taenia solium cysts in the central nervous system. Murine cysticercosis by Taenia crassiceps is a useful model of cysticercosis in which the complement component 5 (C5) has been linked to infection resistance/permissiveness. This work aimed to study the possible relevance for human neurocysticercosis of single nucleotide polymorphisms (SNPs) in the C5-TRAF1 region (rs17611 C/T, rs992670 G/A, rs25681 G/A, rs10818488 A/G, and rs3761847 G/A) in a Mexican population and associated with clinical and radiological traits related to neurocysticercosis severity (cell count in the cerebrospinal fluid [CSF cellularity], parasite location and parasite load in the brain, parasite degenerating stage, and epilepsy). The AG genotype of the rs3761847 SNP showed a tendency to associate with multiple brain parasites, while the CT and GG genotypes of the rs17611 and rs3761847 SNPs, respectively, showed a tendency to associate with low CSF cellularity. The rs3761847 SNP was associated with epilepsy under a dominant model, whereas rs10818488 was associated with CSF cellularity and parasite load under dominant and recessive models, respectively. For haplotypes, C5- and the TRAF1-associated SNPs were, respectively, in strong linkage disequilibrium with each other; thus, these haplotypes were studied independently. For C5 SNPs, carrying the CAA haplotype increases the risk of showing high CSF cellularity 3-fold and the risk of having extraparenchymal parasites 4-fold, two conditions that are related to severe disease. For TRAF1 SNPs, the GA and AG haplotypes were associated with CSF cellularity, and the AG haplotype was associated with epilepsy. Overall, these findings support the clear participation of C5 and TRAF1 in the risk of developing severe neurocysticercosis in the Mexican population. Copyright © 2019 American Society for Microbiology.
Filiaciones:
Villegas, Marcela:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Mexico City, DF, Mexico
Sciutto, Edda:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico
Rosetti, Marcos:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
Unidad Psicopatología y Desarrollo, Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico
Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Unidad Psicopatol & Desarrollo, Mexico City, DF, Mexico
Fleury, Agnes:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
Unidad Periférica del Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México en el Instituto Nacional de Neurología y Neurocirugía Dr. Manuel Velasco SuárezMexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Unidad Perifer Inst Invest Biomed, Inst Nacl Neurol & Neurocirugia Dr Manuel Velasco, Mexico City, DF, Mexico
Fragoso, Gladis:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico
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