Neutrophil Extracellular Traps: Current Perspectives in the Eye
Por:
Alejandro Estua-Acosta, Gibrin, Zamora-Ortiz, Rocio, Buentello-Volante, Beatriz, Garcia-Mejia, Mariana, Garfias, Yonathan
Publicada:
1 sep 2019
Categoría:
Biochemistry, genetics and molecular biology (miscellaneous)
Resumen:
Neutrophil extracellular traps (NETs) have been the subject of research
in the field of innate immunity since their first description more than
a decade ago. Neutrophils are the first cells recruited at sites of
inflammation, where they perform their specific functions, including the
release of NETs, which consist of web-like structures composed of
granule proteins bound to decondensed chromatin fibres. This process has
aroused interest, as it contributes to understanding how pathogenic
microorganisms are contained, but they are also associated with
pathophysiological processes of a wide range of diseases. Currently,
there are growing reports of new molecules involved in the formation and
release of NETs. However, whether the release of NETs contributes to eye
diseases remains unclear. For this reason, the overall aim of this
review is to gather current data of recent research in the ophthalmology
field, where there is still much to discover.
Filiaciones:
Alejandro Estua-Acosta, Gibrin:
Inst Ophthalmol Conde Valenciana, Cell & Tissue Biol, Res Unit, Mexico City 06800, DF, Mexico
Zamora-Ortiz, Rocio:
Inst Ophthalmol Conde Valenciana, Cell & Tissue Biol, Res Unit, Mexico City 06800, DF, Mexico
Buentello-Volante, Beatriz:
Inst Ophthalmol Conde Valenciana, Cell & Tissue Biol, Res Unit, Mexico City 06800, DF, Mexico
Garcia-Mejia, Mariana:
Inst Ophthalmol Conde Valenciana, Cell & Tissue Biol, Res Unit, Mexico City 06800, DF, Mexico
Garfias, Yonathan:
Inst Ophthalmol Conde Valenciana, Cell & Tissue Biol, Res Unit, Mexico City 06800, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Mexico City 04510, DF, Mexico
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