Anticancer activity ofwater-soluble olsalazine-pamam-dendrimer-salicylic acid-conjugates
Por:
Cortez-Maya, Sandra, Pedro-Hernandez, Luis Daniel, Martinez-Klimova, Elena, Ramirez-Apan, Teresa, Martinez-Garcia, Marcos
Publicada:
1 ene 2019
Resumen:
Improving the activity and selectivity profile of anticancer agents will require designing drug carrier systems that employ soluble macromolecules. Olsalazine-PAMAM-dendrimer-salicylic acid-conjugates with dendritic arms of different lengths have shown good stability regarding the chemical link between drug and spacer. In this study, the drug release was followed in vitro by ultraviolet (UV) studies. Evaluation of the cytotoxicity of the olsalazine-PAMAM-dendrimer-salicylic acid-conjugates employing a sulforhodamine B (SRB) assay in PC-3 (human prostatic adenocarcinoma) and MCF-7 (human mammary adenocarcinoma) cell lines demonstrated that conjugate 9 was more active as an antiproliferative agent than cisplatin, and no cytotoxicity towards the African green monkey kidney fibroblast (COS-7) cell line was observed in any of the conjugates synthesized in the present work. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Filiaciones:
Cortez-Maya, Sandra:
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán, México D.F, C.P. 04510, Mexico
Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico
Pedro-Hernandez, Luis Daniel:
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán, México D.F, C.P. 04510, Mexico
Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico
Martinez-Klimova, Elena:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Interior, Coyoacán, México D.F, C.P. 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Ciudad Univ, Mexico City 04510, DF, Mexico
Ramirez-Apan, Teresa:
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán, México D.F, C.P. 04510, Mexico
Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico
Martinez-Garcia, Marcos:
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán, México D.F, C.P. 04510, Mexico
Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico
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