Seroprevalence of HPV serotypes 6, 11, 16 and 18 in unvaccinated children from Mexico City
Por:
Pacheco-Domínguez R.L., Durazo-Arvizu, Ramon A., Lopez-Hernandez, Angelica, Figueroa-Padilla, Jesica, Ramírez-González J.B., Lopez-Cervantes, Malaquias
Publicada:
1 ene 2019
Resumen:
Data regarding humoral immunity against HPV infection are scarce. Most analyses focus on the identification of viruses on mucous membranes and primarily refer to women of reproductive age. The aim of this work was to estimate the seroprevalence of antibodies against HPV serotypes 6, 11, 16 and 18 among unvaccinated boys living in Mexico City. A cross-sectional study of 257 male students from 48 public primary schools in Mexico City, whose ages fluctuated between 9 and 14 years, was carried out. Immunological status was assessed by applying the competitive Luminex Immunoassay of HPV (cLIA). Among the study population, we initially found that 38.52% (n = 99) of the children tested positive against one or more of the HPV 6, 11, 16 and/or 18 serotypes. The most commonly found serotype was isolated HPV 18 or in combination with other serotypes (22% and 31%, respectively), followed by HPV 6 with frequencies of 4.7% and 11%, respectively; however, lower frequencies were estimated for HPV 16 (2%; 6%) and isolated HPV 11, 4%. If a second set of cut-off points for seropositivity is applied, the overall prevalence for any serotype is reduced to 15.2%. As it appears that a significant sector of the study population has had basal contact with an HPV serotype, we recommend considering the possibility of vaccination against HPV at earlier ages.
Filiaciones:
Pacheco-Domínguez R.L.:
National Autonomous University of Mexico, Faculty of Medicine, Research Center on Population and Health Policies, Mexico City, Mexico
Durazo-Arvizu, Ramon A.:
Department of Public Health, Loyola University Stritch School of Medicine, Mexico City, Mexico
Loyola Univ, Stritch Sch Med, Dept Publ Hlth, Mexico City, DF, Mexico
Lopez-Hernandez, Angelica:
National Autonomous University of Mexico, Faculty of Medicine, Research Center on Population and Health Policies, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Res Ctr Populat & Hlth Policies, Mexico City, DF, Mexico
Figueroa-Padilla, Jesica:
National Autonomous University of Mexico, Faculty of Medicine, Research Center on Population and Health Policies, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Res Ctr Populat & Hlth Policies, Mexico City, DF, Mexico
Ramírez-González J.B.:
National Autonomous University of Mexico, Faculty of Medicine, Research Center on Population and Health Policies, Mexico City, Mexico
Lopez-Cervantes, Malaquias:
National Autonomous University of Mexico, Faculty of Medicine, Research Center on Population and Health Policies, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Res Ctr Populat & Hlth Policies, Mexico City, DF, Mexico
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