Liver disease in pregnancy: Medical aspects and their implications for mother and child
Por:
García-Romero C.S., Guzman, Carolina, Cervantes, Alicia, Cerbon, Marco
Publicada:
1 ene 2019
Resumen:
Liver disease during pregnancy is more common than expected and may require specialized intervention. It is important to determine if changes in liver physiology may develop into liver disease, to assure early diagnosis. For adequate surveillance of mother-fetus health outcome, liver disease during pregnancy might require intervention from a hepatologist. Liver diseases have a prevalence of at least 3% of all pregnancies in developed countries, and they are classified into two main categories: related to pregnancy; and those non- related that are present de novo or are preexisting chronic liver diseases. In this review we describe and discuss the main characteristics of those liver diseases associated with pregnancy and only some frequent pre-existing and co-incidental in pregnancy are considered. In addition to the literature review, we compiled the data of liver disease occurring during pregnancies attended at the National Institute of Perinatology in Mexico City in a three-year period. In our tertiary referral women hospital, liver disease was present in 11.24 % of all pregnancies. Associated liver disease was found in 10.8% of all pregnancies, mainly those related to pre-eclampsia (9.9% of pregnancies). Only 0.56% was due to liver disease that was co-incidental or preexisting; the acute or chronic hepatitis C virus was the most frequent in this group (0.12%). When managing pregnancy in referral hospitals in Latin America, it is important to discard liver alterations early for adequate follow up of the disease and to prevent adverse consequences for the mother and child. Copyright © 2019 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. All rights reserved.
Filiaciones:
García-Romero C.S.:
Laboratorio de Biología Molecular y Virología, Instituto Nacional de Perinatología, Mexico City, Mexico
Guzman, Carolina:
Laboratorio de Hígado, Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM)/Hospital General de México Dr. Eduardo Liceaga, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Hosp Gen Mexico Dr Eduardo Liceaga, Lab Higado Pancreas & Motilidad, Unidad Med Expt,Fac Med, Mexico City, DF, Mexico
Cervantes, Alicia:
Servicio de Genética, Hospital General de México Dr. Eduardo Liceaga/Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Hosp Gen Mexico Dr Eduardo Liceaga, Serv Genet, Dr Balmis 148,Torre 501 Tercer Piso, Mexico City 06726, DF, Mexico
Cerbon, Marco:
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Inst Nacl Perinatol, Unidad Invest Reprod Humana, Mexico City, DF, Mexico
Inst Nacl Perinatol, Lab Biol Mol & Virol, Mexico City, DF, Mexico
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