The immune response to Hymenolepis nana in mice decreases tumorigenesis induced by 7,12 dimethylbenz-anthracene
Por:
Ramos-Martinez, E., Rojas-Serrano, J., Garcia-Hernandez, O., Garcia-Vazquez, F. J., Andrade, W. A., Avila, G., Salinas-Pasquier, L., Lopez-Vancell, M. R.
Publicada:
1 ene 2019
Resumen:
Background: Cancer is a high-impact disease throughout the world. A negative correlation has been established between the development of cancer and the Th2 immune response. Infection by helminth parasites is characterized by the induction of a strong and long-lasting Th2 response. The aim of this work was to evaluate the effect of the immune response induced by the infection with the helminth Hymenolepis nana, on the tumorigenesis induced by dimethylbenz-anthracene (DMBA) in mice. Methodology: Four different groups of 14 female BALB/c mice were formed; Group A, dimethyl sulfoxide (DMSO) (vehicle) was administered cutaneously, Group B infected with H. nana, group C, cutaneously DMBA and finally Group D infected with H. nana and cutaneous DMBA. The tumor load was determined in those animals that developed cancerous lesions. In all groups were determined: serum concentration of IgE, IFN?, IL-10, IL-5 and malondialdehyde (MDA). The inflammatory infiltrate was analyzed from skin samples and the expression of the main eosinophilic protein and myeloperoxidase was determined. Results: The group previously infected with H. nana had a reduced amount of tumors with smaller size, in comparison to the group that received only DMBA; this reduction was associated with lower levels of IFN? and IL-10, while levels of IgE, IL-5 and MDA were higher. Further, the number of eosinophils and neutrophils was statistically higher in the animals that were previously infected with the helminth and developed less tumors. Conclusion: The immune response induced by H. nana infection is associated with the reduction of tumors probably due to the activity of eosinophils and neutrophils. © 2019 Elsevier Ltd
Filiaciones:
Ramos-Martinez, E.:
Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Med Expt, Mexico City, DF, Mexico
Rojas-Serrano, J.:
Servicio Clínico de enfermedades del Intersticio del Pulmón y Reumatología Instituto Nacional de Enfermedades Respiratorias, “Ismael Cosío Villegas”, Ciudad de México, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Serv Clin Enfermedades Intersticio Pulmon & Reuma, Mexico City, DF, Mexico
Garcia-Hernandez, O.:
Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Med Expt, Mexico City, DF, Mexico
Garcia-Vazquez, F. J.:
Instituto Nacional de Pediatría, Laboratorio de Inmunogenética Molecular, Departamento de Análisis Clínicos y Estudios Especiales, México, DF, Mexico
Inst Nacl Pediat, Lab Inmunogenet Mol, Dept Anal Clin & Estudios Especiales, Mexico City, DF, Mexico
Andrade, W. A.:
Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biol Celular & Mol & Bioagentes Patogen, Ribeirao Preto, SP, Brazil
Avila, G.:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Mexico City, DF, Mexico
Salinas-Pasquier, L.:
Servicio de Anatomía Patológica, Unidad de Citopatología. Hospital General de México “Dr. Eduardo Liceaga”, Ciudad de México, Mexico
Hosp Gen Mexico Dr Eduardo Liceaga, Unidad Citopatol, Serv Anat Patol, Mexico City, DF, Mexico
Lopez-Vancell, M. R.:
Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Med Expt, Mexico City, DF, Mexico
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