Oxidative Stress as a Mechanism Involved in Kidney Damage After Subchronic Exposure to Vanadium Inhalation and Oral Sweetened Beverages in a Mouse Model
Por:
Espinosa-Zurutuza, Maribel, Gonzalez-Villalva, Adriana, Carlos Albarran-Alonso, Juan, Colin-Barenque, Laura, Bizarro-Nevares, Patricia, Rojas-Lemus, Marcela, Lopez-Valdez, Nelly, Fortoul, Teresa I.
Publicada:
1 ene 2018
Categoría:
Toxicology
Resumen:
Kidney diseases have notably increased in the last few years. This is
partially explained by the increase in metabolic syndrome, diabetes, and
systemic blood hypertension. However, there is a segment of the
population that has neither of the previous risk factors, yet suffers
kidney damage. Exposure to atmospheric pollutants has been suggested as
a possible risk factor. Air-suspended particles carry on their surface a
variety of fuel combustion-related residues such as metals, and vanadium
is one of these. Vanadium might produce oxidative stress resulting in
the damage of some organs such as the kidney. Additionally, in countries
like Mexico, the ingestion of sweetened beverages is a major issue;
whether these beverages alone are responsible for direct kidney damage
or whether their ingestion promotes the progression of an existing renal
damage generates controversy. In this study, we report the combined
effect of vanadium inhalation and sweetened beverages ingestion in a
mouse model. Forty CD-1 male mice were distributed in 4 groups: control,
vanadium inhalation, 30% sucrose in drinking water, and vanadium
inhalation plus sucrose 30% in drinking water. Our results support that
vanadium inhalation and the ingestion of 30% sucrose induce functional
and histological kidney damage and an increase in oxidative stress
biomarkers, which were higher in the combined effect of vanadium plus
30% sucrose. The results also support that the ingestion of 30%
sucrose alone without hyperglycemia also produces kidney damage.
Filiaciones:
Espinosa-Zurutuza, Maribel:
Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico
Gonzalez-Villalva, Adriana:
Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico
Carlos Albarran-Alonso, Juan:
Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico
Colin-Barenque, Laura:
FES Iztacala, Lab Neuromorfol, Mexico City, DF, Mexico
Bizarro-Nevares, Patricia:
Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico
Rojas-Lemus, Marcela:
Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico
Lopez-Valdez, Nelly:
Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico
Fortoul, Teresa I.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico
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