INFLUENCE OF THE SUPERDISINTEGRANTS IN NIFEDIPINE RELEASE FROM OSMOTIC PUSH-PULL TABLETS
Por:
Hernandez Torres, J. E., Hernandez Baltazar, E., Bernad Bernad, M. J., Melgoza Contreras, L. M.
Publicada:
1 may 2019
Resumen:
Push-pull osmotic pumps are controlled drug delivery systems for drugs
with a broad range of solubilities; especially drugs that are poorly
water-soluble. The aim of the present study was to evaluate the
performance of the superdisintegrants (SD), crospovidone (CPVP),
croscarmellose sodium (CS), and sodium starch glycolate (SSG), in
push-pull tablets containing Nifedipine (NP) as a model drug. We
performed an in-vitro dissolution test with phosphate buffer (0.05M) at
pH 7.5 for 12 h. The amount of released NP was determined using a
UV/Visible spectro-photometric method at a wavelength of 238 nm. At 12 h
of release, the profile of CPVP- and CS-containing osmotic tablets was
like that of the reference product Adalat OROS (R), whereas the
SSG-containing tablet showed differences. It is very important mention
that in the first 6 h of the assay, all release profiles were different
compared to the commercially available reference product. The tablets
containing superdisintegrants showed faster drug delivery rates and a
reduction in lag time.
Filiaciones:
Hernandez Torres, J. E.:
Univ Autonoma Metropolitana Xochimilco, Ciencias Farmaceut, Mexico City, DF, Mexico
Univ Autonoma Metropolitana Xochimilco, Dept Sistemas Biol, Mexico City, DF, Mexico
Hernandez Baltazar, E.:
Univ Autonoma Estado Morelos, Fac Farm, Morelos, Morelos, Mexico
Bernad Bernad, M. J.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, DF, Mexico
Melgoza Contreras, L. M.:
Univ Autonoma Metropolitana Xochimilco, Ciencias Farmaceut, Mexico City, DF, Mexico
Univ Autonoma Metropolitana Xochimilco, Dept Sistemas Biol, Mexico City, DF, Mexico
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