Progesterone Actions During Central Nervous System Development
Por:
Carlos Gonzalez-Orozco, Juan, Camacho-Arroyo I.
Publicada:
17 may 2019
Categoría:
Neuroscience (miscellaneous)
Resumen:
Although progesterone is a steroid hormone mainly associated with female
reproductive functions, such as uterine receptivity and maintenance of
pregnancy, accumulating data have shown its physiological actions to
extend to several non-reproductive functions in the central nervous
system (CNS) both in males and females. In fact, progesterone is de novo
synthesized in specific brain regions by neurons and glial cells and is
involved in the regulation of various molecular and cellular processes
underlying myelination, neuroprotection, neuromodulation, learning and
memory, and mood. Furthermore, progesterone has been reported to be
implicated in critical developmental events, such as cell
differentiation and neural circuits formation. This view is supported by
the increase in progesterone synthesis observed during pregnancy in both
the placenta and the fetal brain. In the present review, we will focus
on progesterone actions during CNS development.
Filiaciones:
Carlos Gonzalez-Orozco, Juan:
Univ Nacl Autonoma Mexico, Fac Quim, Inst Nacl Perinatol, Unidad Invest Reprod Humana, Mexico City, DF, Mexico
Camacho-Arroyo I.:
Univ Nacl Autonoma Mexico, Fac Quim, Inst Nacl Perinatol, Unidad Invest Reprod Humana, Mexico City, DF, Mexico
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico
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