DNA methylation in the pathogenesis of polycystic ovary syndrome
Por:
Ricardo Vazquez-Martinez, Edgar, Ines Gomez-Viais, Yadira, Garcia-Gomez, Elizabeth, Reyes-Mayoral, Christian, Reyes-Munoz, Enrique, Camacho-Arroyo, Ignacio, Cerbon, Marco
Publicada:
1 jul 2019
Resumen:
Polycystic ovary syndrome (PCOS) is the leading endocrine and metabolic
disorder in premenopausal women characterized by hyperandrogenism and
abnormal development of ovarian follicles. To date, the PCOS etiology
remains unclear and has been related to insulin resistance, obesity,
type 2 diabetes mellitus, cardiovascular disease and infertility, among
other morbidities. Substantial evidence illustrates the impact of
genetic, intrauterine and environmental factors on the PCOS etiology.
Lately, epigenetic factors have garnered considerable attention in the
pathogenesis of PCOS considering that changes in the content of DNA
methylation, histone acetylation and noncoding RNAs have been reported
in various tissues of women with this disease. DNA methylation is
changed in the peripheral and umbilical cord blood, as well as in
ovarian and adipose tissue of women with PCOS, suggesting the
involvement of this epigenetic modification in the pathogenesis of the
disease. Perhaps, these defects in DNA methylation promote the
deregulation of genes involved in inflammation, hormone synthesis and
signaling and glucose and lipid metabolism. Research on the role of DNA
methylation in the pathogenesis of PCOS is just beginning, and several
issues await investigation. This review aims to provide an overview of
current research focused on DNA methylation and PCOS, as well as discuss
the perspectives regarding this topic.
Filiaciones:
Ricardo Vazquez-Martinez, Edgar:
Univ Nacl Autonoma Mexico, Fac Quim, Inst Nacl Perinatol, Unidad Invest Reprod Humana, Ciudad De Mexico, Mexico
Ines Gomez-Viais, Yadira:
Univ Nacl Autonoma Mexico, Fac Quim, Inst Nacl Perinatol, Unidad Invest Reprod Humana, Ciudad De Mexico, Mexico
Garcia-Gomez, Elizabeth:
Consejo Nacl Ciencia & Tecnol CONACyT, Inst Nacl Perinatol, Unidad Invest Reprod Humana, Ciudad De Mexico, Mexico
Unidad de Investigación en Reproducción Humana, Consejo Nacional de Ciencia y Tecnología (CONACyT), Instituto Nacional de Perinatología, Ciudad de México, Mexico
Reyes-Mayoral, Christian:
Inst Nacl Perinatol Isidro Espinosa de los Reyes, Subdirecc Reprod Humana, Ciudad De Mexico, Mexico
Subdirección de Reproducción Humana, Instituto Nacional de Perinatología ‘Isidro Espinosa de los Reyes’, Ciudad de México, Mexico
Reyes-Munoz, Enrique:
Inst Nacl Perinatol Isidro Espinosa de los Reyes, Coordinac Endocrinol Ginecol & Perinatal, Ciudad De Mexico, Mexico
Coordinación de Endocrinología Ginecológica y Perinatal, Instituto Nacional de Perinatología ‘Isidro Espinosa de los Reyes’, Ciudad de México, Mexico
Camacho-Arroyo, Ignacio:
Univ Nacl Autonoma Mexico, Fac Quim, Inst Nacl Perinatol, Unidad Invest Reprod Humana, Ciudad De Mexico, Mexico
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Cerbon, Marco:
Univ Nacl Autonoma Mexico, Fac Quim, Inst Nacl Perinatol, Unidad Invest Reprod Humana, Ciudad De Mexico, Mexico
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
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