Mycobacterium tuberculosis and Mycobacterium bovis derived proteins induce caspase-independent apoptosis in bovine macrophages
Por:
Maciel Rivera, Anaid, Flores Villalva, Susana, Jimenez Vazquez, Itzel, Catalan Barcenas, Omar, Espitia Pinzon, Clara, Moran, Julio, Arriaga-Pizano, Lourdes, Benitez Guzman, Alejandro, Alfonseca Silva, Edgar, Angel Gutierrez-Pabello, Jose
Publicada:
1 ene 2019
Categoría:
Veterinary (miscellaneous)
Resumen:
Species of the genus Mycobacterium are capable of inducing cell
apoptosis. Infected cells with M. tuberculosis undergo apoptosis through
a caspase-dependent pathway. We have previously shown that whole
Mycobacterium bovis cells and derived crude protein extracts were able
to trigger apoptosis through a caspase independent mechanism. However,
the identity of the protein or protein fractions capable of inducing
apoptosis has not been determined. In this study, bovine macrophages
were incubated in the presence of Mycobacterium tuberculosis recombinant
proteins and Mycobacterium bovis protein extracts to identify proteins
capable of inducing apoptosis. A subgroup of proteins and protein
extracts from strains of the Mycobacterium tuberculosis complex were
shown to induce DNA fragmentation in bovine macrophages through a
caspase independent pathway. Our findings suggest that bovine
macrophages may elicit a different response to mycobacterium infection
than that displayed by murine or human cells.
Filiaciones:
Maciel Rivera, Anaid:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Ciudad De Mexico, Mexico
Flores Villalva, Susana:
INIFAP, Ctr Nacl Invest Disciplinaria CENID Fisiol, Queretaro, Mexico
Jimenez Vazquez, Itzel:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Ciudad De Mexico, Mexico
Catalan Barcenas, Omar:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Ciudad De Mexico, Mexico
Espitia Pinzon, Clara:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Ciudad De Mexico, Mexico
Moran, Julio:
Univ Nacl Autonoma Mexico, Inst Fis Celular, Ciudad De Mexico, Mexico
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Arriaga-Pizano, Lourdes:
Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Unided Invest Med Inmunoquim, Ciudad De Mexico, Mexico
Unidad de Investigación Médica en Inmunoquímica, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico
Benitez Guzman, Alejandro:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Ciudad De Mexico, Mexico
Alfonseca Silva, Edgar:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Ciudad De Mexico, Mexico
Angel Gutierrez-Pabello, Jose:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Ciudad De Mexico, Mexico
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Centro Nacional de Investigación Disciplinaria (CENID) Fisiología, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias (INIFAP), Querétaro, Mexico
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
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