A higher fructose intake is associated with greater albuminuria in subjects with type 2 diabetes mellitus
Por:
Gómez-Sámano M.Á., Almeda-Valdes P., Cuevas-Ramos D., Navarro-Flores M.F., Espinosa-Salazar H.D., Martínez-Saavedra M., León-Domínguez J.A., Enríquez-Estrada V.M., López-González A.L., Sarmiento-Moreno A.L., Rivera-González L.A., Juárez-León Ó.A., Pérez-González B., Ávila-Palacios Y., Sigala-Pedroza L., Huerta-Ávila E., Vargas-Álvarez M.A., Sánchez-Jaimes C., Cárdenas-Vera M., Mehta R., La Torre M.A.L.-F.A., Manjarrez-Martínez I., Brito-Córdova G.X., Zuarth-Vázquez J.M., Vega-Beyhart A., López-Carrasco G., Johnson R.J., Gómez-Pérez F.J.
Publicada:
1 ene 2018
Categoría:
Nephrology
Resumen:
The aim of this single center cross-sectional study was to investigate the association between fructose intake and albuminuria in subjects with type 2 diabetes mellitus (T2DM). This is a single center cross-sectional study. One hundred and forty-three subjects with T2DM were recruited from the Instituto Nacional de Ciencias Medicas ? Nutricion Salvador Zubiran. The median daily fructose intake was estimated with a prospective food registry during 3 days (2 week-days and one weekend day) and they were divided into low fructose intake (<25 g/day) and high fructose intake (= 25 g/day). Complete clinical and biochemical evaluations were performed, including anthropometric variables and a 24-hour urine collection for albuminuria determination. One hundred and thirty-six subjects were analyzed in this study. We found a positive significant association between daily fructose intake and albuminuria (p= 0.178, p=0.038) in subjects with type 2 diabetes mellitus. Other variables significantly associated with albuminuria were body mass index (BMI) (p= 0.170, p=0.048), mean arterial pressure (MAP) (p= 0.280, p=0.001), glycated hemoglobin (A1c) (p= 0.197, p=0.022), and triglycerides (p= 0.219, p=0.010). After adjustment for confounding variables we found a significant and independent association between fructose intake and albuminuria (ß= 13.96, p=0.006). We found a statistically significant higher albuminuria (60.8 [12.8-228.5] versus 232.2 [27.2-1273.0] mg/day, p 0.002), glycated hemoglobin (8.6±1.61 versus 9.6±2.1 %), p= 0.003, and uric acid (6.27±1.8 versus 7.2±1.5 mg/dL), p=0.012, in the group of high fructose intake versus the group with low fructose intake, and a statistically significant lower creatinine clearance (76.5±30.98 mL/min versus 94.9±36.8, p=0.014) in the group with high fructose intake versus the group with low fructose intake. In summary we found that a higher fructose intake is associated with greater albuminuria in subjects with T2DM. Copyright © 2018 Miguel Angel Gómez-Sámano et al.
Filiaciones:
Gómez-Sámano M.Á.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Almeda-Valdes P.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Cuevas-Ramos D.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Espinosa-Salazar H.D.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
López-González A.L.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Sarmiento-Moreno A.L.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Rivera-González L.A.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Juárez-León Ó.A.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Pérez-González B.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Ávila-Palacios Y.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Sigala-Pedroza L.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Huerta-Ávila E.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Sánchez-Jaimes C.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Cárdenas-Vera M.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Mehta R.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
La Torre M.A.L.-F.A.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Brito-Córdova G.X.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Zuarth-Vázquez J.M.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Vega-Beyhart A.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
López-Carrasco G.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
Johnson R.J.:
Division of Renal Diseases and Hypertension, University of Colorado, Denver, Aurora, 12631, United States
Gómez-Pérez F.J.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 14080, Mexico
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