Persistence of immunity when using different human papillomavirus vaccination schedules and booster-dose effects 5 years after primary vaccination
Por:
Lazcano-Ponce, Eduardo, Torres-Ibarra, Leticia, Cruz-Valdez, Aurelio, Salmeron, Jorge, Barrientos-Gutierrez, Tonatiuh, Prado-Galbarro, Javier, Stanley, Margaret, Munoz, Nubia, Herrero, Rolando, Hernandez-Avila, Mauricio
Publicada:
1 ene 2019
Resumen:
Background There are limited data regarding the duration of immunity induced by different human papillomavirus (HPV) vaccination schedules and the immunogenicity of a booster dose of both bivalent HPV vaccine (bHPV) or quadrivalent HPV vaccine (qHPV). Methods Follow-up of a nonrandomized clinical trial to evaluate the 5-year antibody persistence of the bHPV in girls (age, 9-10 years) and women (age, 18-24 years). Noninferiority of the 2-dose versus 3-dose schedule among girls was evaluated at months 54 (n = 639) and 64 (n = 990). Girls vaccinated with a 2-dose schedule of bHPV or qHPV received a booster dose of either vaccine at month 61. Immunogenicity was measured using a virus-like particle-based enzyme-linked immunosorbent assay. Geometric mean titers (GMTs) for HPV16/18 were estimated after stratification by vaccination schedule and age group. Results At months 54 and 64, the 2-dose schedule remained noninferior to the 3-dose schedule. GMTs remained above natural infection levels across all age groups up to 64 months. After the booster, anti-HPV16/18 GMTs increased exponentially with the same pattern, regardless of vaccine administered. No safety concerns were identified with the booster dose. Conclusions A 2-dose schedule is highly immunogenic in girls, suggesting a high immune memory. Thus, a booster dose is likely to be unprofitable, considering the low global immunization coverage. Clinical Trials Registration NCT01717118. © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.
Filiaciones:
Lazcano-Ponce, Eduardo:
Natl Inst Publ Hlth, Ctr Populat Hlth Res, Univ 655, Cuernavaca 62100, Morelos, Mexico
Center for Population Health Research, National Institute of Public Health, Universidad 655, Colonia Sta. María Ahuacatitlán, Cuernavaca, Morelos, 62100, Mexico
Torres-Ibarra, Leticia:
Natl Inst Publ Hlth, Ctr Populat Hlth Res, Univ 655, Cuernavaca 62100, Morelos, Mexico
Center for Population Health Research, National Institute of Public Health, Universidad 655, Colonia Sta. María Ahuacatitlán, Cuernavaca, Morelos, 62100, Mexico
Cruz-Valdez, Aurelio:
Natl Inst Publ Hlth, Ctr Populat Hlth Res, Univ 655, Cuernavaca 62100, Morelos, Mexico
Center for Population Health Research, National Institute of Public Health, Universidad 655, Colonia Sta. María Ahuacatitlán, Cuernavaca, Morelos, 62100, Mexico
Salmeron, Jorge:
Natl Inst Publ Hlth, Ctr Populat Hlth Res, Univ 655, Cuernavaca 62100, Morelos, Mexico
Univ Nacl Autonoma Mexico, Res Ctr Policies Populat & Hlth, Fac Med, Mexico City, DF, Mexico
Center for Population Health Research, National Institute of Public Health, Universidad 655, Colonia Sta. María Ahuacatitlán, Cuernavaca, Morelos, 62100, Mexico
Research Center on Policies, Population, and Health, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
Barrientos-Gutierrez, Tonatiuh:
Natl Inst Publ Hlth, Ctr Populat Hlth Res, Univ 655, Cuernavaca 62100, Morelos, Mexico
Center for Population Health Research, National Institute of Public Health, Universidad 655, Colonia Sta. María Ahuacatitlán, Cuernavaca, Morelos, 62100, Mexico
Prado-Galbarro, Javier:
Natl Inst Publ Hlth, Ctr Populat Hlth Res, Univ 655, Cuernavaca 62100, Morelos, Mexico
Center for Population Health Research, National Institute of Public Health, Universidad 655, Colonia Sta. María Ahuacatitlán, Cuernavaca, Morelos, 62100, Mexico
Stanley, Margaret:
Univ Cambridge, Dept Pathol, Cambridge, England
Department of Pathology, University of Cambridge, United Kingdom
Munoz, Nubia:
Natl Canc Inst Colombia, Bogota, Colombia
Herrero, Rolando:
Int Agcy Res Canc, Early Detect & Prevent Sect, Lyon, France
Early Detection and Prevention Section, International Agency for Research on Cancer, Lyon, France
Hernandez-Avila, Mauricio:
Natl Inst Publ Hlth, Ctr Populat Hlth Res, Univ 655, Cuernavaca 62100, Morelos, Mexico
Center for Population Health Research, National Institute of Public Health, Universidad 655, Colonia Sta. María Ahuacatitlán, Cuernavaca, Morelos, 62100, Mexico
National Cancer Institute of Colombia, Bogotá, Colombia
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