Bicyclic acetals: biological relevance, scaffold analysis, and applications in diversity-oriented synthesis
Por:
Lenci E., Menchi G., Saldívar-Gonzalez F.I., Medina-Franco J.L., Trabocchi A.
Publicada:
7 feb 2019
Resumen:
Natural products (NPs) have been shown to be an extraordinary source of
bioactive compounds and three-dimensional complex frameworks that can be
useful to produce high-value molecular collections that are able to
address ``undruggable'' and difficult therapeutic targets. Bicyclic
acetals are particularly relevant for these purposes, given their key
role in several biological interactions and the structural and
stereochemical diversity that comes from the many possible ring
combinations. To investigate this topological diversity, we have
systematically characterized in a systematic and detailed manner fused,
spiro and bridged bicyclic acetals in a large set of NPs, highlighting
the great potential of bicyclic acetals in Diversity-Oriented Synthesis
(DOS). Accordingly, a summary of some recent efforts on the development
of acetal-containing small molecule collections through DOS approaches
is herein reported.
Filiaciones:
Lenci E.:
Department of Chemistry Ugo Schiff, University of Florence, Via della Lastruccia 13, Sesto Fiorentino Florence, 50019, Italy
Univ Florence, Dept Chem Ugo Schiff, Via Lastruccia 13, I-50019 Florence, Italy
Menchi G.:
Department of Chemistry Ugo Schiff, University of Florence, Via della Lastruccia 13, Sesto Fiorentino Florence, 50019, Italy
Interdepartmental Center for Preclinical Development of Molecular Imaging (CISPIM), University of Florence, Viale Morgagni 85, Florence, 50134, Italy
Univ Florence, Dept Chem Ugo Schiff, Via Lastruccia 13, I-50019 Florence, Italy
Univ Florence, Interdept Ctr Preclin Dev Mol Imaging CISPIM, Viale Morgagni 85, I-50134 Florence, Italy
Saldívar-Gonzalez F.I.:
School of Chemistry, Department of Pharmacy, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Dept Pharm, Sch Chem, Ave Univ 3000, Mexico City 04510, DF, Mexico
Medina-Franco J.L.:
School of Chemistry, Department of Pharmacy, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Dept Pharm, Sch Chem, Ave Univ 3000, Mexico City 04510, DF, Mexico
Trabocchi A.:
Department of Chemistry Ugo Schiff, University of Florence, Via della Lastruccia 13, Sesto Fiorentino Florence, 50019, Italy
Interdepartmental Center for Preclinical Development of Molecular Imaging (CISPIM), University of Florence, Viale Morgagni 85, Florence, 50134, Italy
Univ Florence, Dept Chem Ugo Schiff, Via Lastruccia 13, I-50019 Florence, Italy
Univ Florence, Interdept Ctr Preclin Dev Mol Imaging CISPIM, Viale Morgagni 85, I-50134 Florence, Italy
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