Metabolic engineering strategies for caffeic acid production in Escherichia coli
Por:
Hernandez-Chavez, Georgina, Martinez, Alfredo, Gosset, Guillermo
Publicada:
1 mar 2019
Resumen:
Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is an aromatic compound
obtained by the phenylpropanoid pathway. This natural product has
antioxidant, antitumor, antiviral, and anti-inflammatory activities. It
is also a precursor of CA phenethyl ester (CAPE), a compound with
potential as an antidiabetic and liver-protective agent. CA can be found
at low concentrations in plant tissues, and hence, its purification is
difficult and expensive. Knowledge regarding the pathways, enzymes, and
genes involved in CA biosynthesis has paved the way for enabling the
design and construction of microbial strains with the capacity of
synthesizing this metabolite. In this review, metabolic engineering
strategies for the generation of Escherichia coli strains for the
biotechnological production of CA are presented and discussed. (C) 2019
Pontificia Universidad Catolica de Valparaiso. Production and hosting by
Elsevier B.V. All rights reserved.
Filiaciones:
Hernandez-Chavez, Georgina:
Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apdo. Postal 510-3, Cuernavaca, Morelos 62250, Mexico
Univ Nacl Autonoma Mexico, Inst Biotecnol, Dept Ingn Celular & Biocatalisis, Apdo Postal 510-3, Cuernavaca 62250, Morelos, Mexico
Martinez, Alfredo:
Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apdo. Postal 510-3, Cuernavaca, Morelos 62250, Mexico
Univ Nacl Autonoma Mexico, Inst Biotecnol, Dept Ingn Celular & Biocatalisis, Apdo Postal 510-3, Cuernavaca 62250, Morelos, Mexico
Gosset, Guillermo:
Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apdo. Postal 510-3, Cuernavaca, Morelos 62250, Mexico
Univ Nacl Autonoma Mexico, Inst Biotecnol, Dept Ingn Celular & Biocatalisis, Apdo Postal 510-3, Cuernavaca 62250, Morelos, Mexico
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