Synthetic cementum protein 1-derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo
Por:
Correa, Rodrigo, Arenas, Jesus, Montoya, Gonzalo, Hoz, Lia, Lopez, Sonia, Salgado, Fabiola, Arroyo, Rita, Salmeron, Nahum, Romo, Enrique, Zeichner-David, Margarita, Arzate, Higinio
Publicada:
1 ene 2019
Resumen:
The use of recombinant proteins has revolutionized the development of
biologic pharmaceuticals; however, they are not free of complications.
Some have very high molecular weight, some demonstrate in vivo
instability, and the high cost of producing them remains a major
problem. On the other hand, it has been shown that peptides derived from
active domains keep their biologic activity and can trigger events, such
as osteogenesis and bone regeneration. Small peptides are advantageous
because of their ease of synthesis and handling and their low
immunogenic activity. The purpose of this study was to investigate the
functions of a synthetic peptide, cementum protein 1-peptide1
(CEMP-1-p1), both in vitro and in vivo. Our results show that CEMP-1-p1
significantly enhanced the proliferation and differentiation of human
periodontal ligament cells toward a mineralizing-like phenotype, as
evidenced by increasing alkaline phosphatase (ALP)-specific activity and
osterix, runt-related transcription factor (RUNX)-2, integrin binding
sialoprotein, bone morphogenetic protein-2, osteocalcin, and cementum
protein (CEMP)-1 expression at mRNA and protein levels. In vivo assays
performed through standardized critical-size calvarial defects in rats
treated with CEMP-1-p1 resulted in newly formed bone after 30 and 60 d.
These data demonstrate that CEMP-1-p1 is an effective bioactive peptide
for bone tissue regeneration. The application of this bioactive peptide
may lead to implementing new strategies for the regeneration of bone and
other mineralized tissues.Correa, R., Arenas, J., Montoya, G., Hoz, L.,
Lopez, S., Salgado, F., Arroyo, R., Salmeron, N., Romo, E.,
Zeichner-David, M., Arzate, H. Synthetic cementum protein 1-derived
peptide regulates mineralization in vitro and promotes bone regeneration
in vivo.
Filiaciones:
Correa, Rodrigo:
Laboratorio de Biolo?ia Periodontal, Facultad de Odontolo?ia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 3000, C.P., Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Lab Biol Periodontal, Fac Odontol, Ave Univ 3000, Mexico City 04510, DF, Mexico
Arenas, Jesus:
Instituto de Fisica, Universidad Nacional Autonoma de M Exico (UNAM), Mexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Fis, Mexico City, DF, Mexico
Montoya, Gonzalo:
Laboratorio de Biolo?ia Periodontal, Facultad de Odontolo?ia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 3000, C.P., Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Lab Biol Periodontal, Fac Odontol, Ave Univ 3000, Mexico City 04510, DF, Mexico
Hoz, Lia:
Laboratorio de Biolo?ia Periodontal, Facultad de Odontolo?ia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 3000, C.P., Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Lab Biol Periodontal, Fac Odontol, Ave Univ 3000, Mexico City 04510, DF, Mexico
Lopez, Sonia:
Laboratorio de Biolo?ia Periodontal, Facultad de Odontolo?ia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 3000, C.P., Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Lab Biol Periodontal, Fac Odontol, Ave Univ 3000, Mexico City 04510, DF, Mexico
Salgado, Fabiola:
Laboratorio de Biolo?ia Periodontal, Facultad de Odontolo?ia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 3000, C.P., Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Lab Biol Periodontal, Fac Odontol, Ave Univ 3000, Mexico City 04510, DF, Mexico
Arroyo, Rita:
Laboratorio de Biolo?ia Periodontal, Facultad de Odontolo?ia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 3000, C.P., Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Lab Biol Periodontal, Fac Odontol, Ave Univ 3000, Mexico City 04510, DF, Mexico
Salmeron, Nahum:
Laboratorio de Biolo?ia Periodontal, Facultad de Odontolo?ia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 3000, C.P., Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Lab Biol Periodontal, Fac Odontol, Ave Univ 3000, Mexico City 04510, DF, Mexico
Romo, Enrique:
Laboratorio de Biolo?ia Periodontal, Facultad de Odontolo?ia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 3000, C.P., Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Lab Biol Periodontal, Fac Odontol, Ave Univ 3000, Mexico City 04510, DF, Mexico
Zeichner-David, Margarita:
Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, United States
Univ Southern Calif, Ostrow Sch Dent, Los Angeles, CA USA
Arzate, Higinio:
Laboratorio de Biolo?ia Periodontal, Facultad de Odontolo?ia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 3000, C.P., Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Lab Biol Periodontal, Fac Odontol, Ave Univ 3000, Mexico City 04510, DF, Mexico
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