Structure-Function Relationships of the Follicle-Stimulating Hormone Receptor
Por:
Ulloa-Aguirre, Alfredo, Zarinan, Teresa, Jardon-Valadez, Eduardo, Gutierrez-Sagal, Ruben, Dias, James A.
Publicada:
29 nov 2018
Categoría:
Endocrinology, diabetes and metabolism
Resumen:
The follicle-stimulating hormone receptor (FSHR) plays a crucial role in
reproduction. This structurally complex receptor is a member of the
G-protein coupled receptor (GPCR) superfamily of membrane receptors. As
with the other structurally similar glycoprotein hormone receptors (the
thyroid-stimulating hormone and luteinizing hormone-chorionic
gonadotropin hormone receptors), the FSHR is characterized by an
extensive extracellular domain, where binding to FSH occurs, linked to
the signal specificity subdomain or hinge region. This region is
involved in ligand-stimulated receptor activation whereas the seven
transmembrane domain is associated with receptor activation and
transmission of the activation process to the intracellular loops
comprised of amino acid sequences, which predicate coupling to
effectors, interaction with adapter proteins, and triggering of
downstream intracellular signaling. In this review, we describe the most
important structural features of the FSHR intimately involved in
regulation of FSHR function, including trafficking, dimerization, and
oligomerization, ligand binding, agonist-stimulated activation, and
signal transduction.
Filiaciones:
Ulloa-Aguirre, Alfredo:
Univ Nacl Autonoma Mexico, Red Apoyo Invest, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico
Zarinan, Teresa:
Univ Nacl Autonoma Mexico, Red Apoyo Invest, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico
Jardon-Valadez, Eduardo:
Univ Autonoma Metropolitana, Dept Ciencias Ambientales, Unidad Lerma, Lerma, Mexico
Gutierrez-Sagal, Ruben:
Univ Nacl Autonoma Mexico, Red Apoyo Invest, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico
Dias, James A.:
SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA
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