The role of gene flow in rapid and repeated evolution of cave-related traits in Mexican tetra, Astyanax mexicanus
Por:
Herman, Adam, Brandvain, Yaniv, Weagley, James, Jeffery, William R., Keene, Alex C., Kono, Thomas J. Y., Bilandzija, Helena, Borowsky, Richard, Espinasa, Luis, O'Quin, Kelly, Ornelas-Garcia, Claudia P., Yoshizawa, Masato, Carlson, Brian, Maldonado, Ernesto, Gross, Joshua B., Cartwright, Reed A., Rohner, Nicolas, Warren, Wesley C., McGaugh, Suzanne E.
Publicada:
1 nov 2018
Resumen:
Understanding the molecular basis of repeatedly evolved phenotypes can
yield key insights into the evolutionary process. Quantifying gene flow
between populations is especially important in interpreting mechanisms
of repeated phenotypic evolution, and genomic analyses have revealed
that admixture occurs more frequently between diverging lineages than
previously thought. In this study, we resequenced 47 whole genomes of
the Mexican tetra from three cave populations, two surface populations
and outgroup samples. We confirmed that cave populations are
polyphyletic and two Astyanax mexicanus lineages are present in our data
set. The two lineages likely diverged much more recently than previous
mitochondrial estimates of 5-7 mya. Divergence of cave populations from
their phylogenetically closest surface population likely occurred
between similar to 161 and 191 k generations ago. The favoured
demographic model for most population pairs accounts for divergence with
secondary contact and heterogeneous gene flow across the genome, and we
rigorously identified gene flow among all lineages sampled. Therefore,
the evolution of cave-related traits occurred more rapidly than
previously thought, and trogolomorphic traits are maintained despite
gene flow with surface populations. The recency of these estimated
divergence events suggests that selection may drive the evolution of
cave-derived traits, as opposed to disuse and drift. Finally, we show
that a key trogolomorphic phenotype QTL is enriched for genomic regions
with low divergence between caves, suggesting that regions important for
cave phenotypes may be transferred between caves via gene flow. Our
study shows that gene flow must be considered in studies of independent,
repeated trait evolution.
Filiaciones:
Herman, Adam:
Univ Minnesota, Gortner Lab, Plant & Microbial Biol, St Paul, MN 55108 USA
Rudjer Boskovic Inst, Dept Mol Biol, Zagreb, Croatia
Brandvain, Yaniv:
Univ Minnesota, Gortner Lab, Plant & Microbial Biol, St Paul, MN 55108 USA
Weagley, James:
Univ Minnesota, Gortner Lab, Ecol Evolut & Behav, St Paul, MN 55108 USA
Washington Univ, Ctr Genome Sci & Syst Biol, St Louis, MO 63130 USA
Washington Univ, Ctr Gut Microbiome & Nutr Res, St Louis, MO 63130 USA
Jeffery, William R.:
Univ Maryland, Dept Biol, College Pk, MD 20742 USA
Keene, Alex C.:
Florida Atlantic Univ, Dept Biol Sci, Jupiter, FL USA
Kono, Thomas J. Y.:
Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN USA
Bilandzija, Helena:
Rudjer Boskovic Inst, Dept Mol Biol, Zagreb, Croatia
Univ Maryland, Dept Biol, College Pk, MD 20742 USA
Borowsky, Richard:
NYU, Dept Biol, New York, NY 10003 USA
Espinasa, Luis:
Marist Coll, Sch Sci, Poughkeepsie, NY USA
O'Quin, Kelly:
Ctr Coll Danville, Dept Biol, Danville, KY USA
Ornelas-Garcia, Claudia P.:
Univ Nacl Autonoma Mexico, Dept Zool, Inst Biol, Coyoacan, Mexico
Yoshizawa, Masato:
Univ Hawaii Manoa, Dept Biol, Honolulu, HI 96822 USA
Carlson, Brian:
Coll Wooster, Dept Biol, Wooster, OH 44691 USA
Maldonado, Ernesto:
Univ Nacl Autonoma Mexico, Unidad Acad Sistemas Arrecifales, Inst Ciencias Mar & Limnol, Puerto Morelos, Mexico
Gross, Joshua B.:
Univ Cincinnati, Dept Biol Sci, Cincinnati, OH USA
Cartwright, Reed A.:
Arizona State Univ, Biodesign Inst, Tempe, AZ USA
Arizona State Univ, Sch Life Sci, Tempe, AZ USA
Rohner, Nicolas:
Stowers Inst Med Res, Kansas City, MO USA
Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66103 USA
Warren, Wesley C.:
Washington Univ, McDonnell Genome Inst, St Louis, MO USA
McGaugh, Suzanne E.:
Rudjer Boskovic Inst, Dept Mol Biol, Zagreb, Croatia
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