Additional alpha-glucosidase inhibitors from Malbranchea flavorosea (Leotiomycetes, Ascomycota)
Por:
Rebollar-Ramos, Daniela, Macias-Ruvalcaba, Martha L., Figueroa, Mario, Raja, Huzefa A., Gonzalez-Andrade, Martin, Mata, Rachel
Publicada:
1 oct 2018
Resumen:
From the rice-based culture of Malbranchea flavorosea, three new
compounds namely flavoroseoside B (5-desoxy-5-chloroflavoroseoside) (2),
4-hydroxy-2-O-alpha-ribofuranosyl-5-methylacetophenone (3), and
(S)-3,4-dihydro-3-(1H-indol-3-ylmethyl)-
4-methyl-1H-1,4-benzodiazepine-2,5-dione (4), along with three known
compounds, rosigenin (5), massarilactone B (6), and riboxylarinol B (7)
were obtained. The structures were determined by spectroscopic methods.
Compound 4 and its synthetic analog
3,4-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-1H-1,4-benzodiazepine-2,5-d
ione (9) inhibited the activity of Ruminococus obeum alpha-glucosidase
enzyme. Molecular docking and dynamic studies revealed that compounds 4
and 9 might bind to this a-glucosidase at the catalytic center.
Phylogenetic analysis using internal transcribed spacer region revealed
that Malbranchea flavorosea ATCC 34529 is related to Myxotrichum spp.
Filiaciones:
Rebollar-Ramos, Daniela:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
Macias-Ruvalcaba, Martha L.:
Univ Nacl Autonoma Mexico, Inst Quim, Dept Prod Nat, Mexico City 04510, DF, Mexico
Figueroa, Mario:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
Raja, Huzefa A.:
Univ North Carolina Greensboro, Dept Chem & Biochem, Greensboro, NC 27402 USA
Gonzalez-Andrade, Martin:
Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Mexico City 04510, DF, Mexico
Mata, Rachel:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
|