Irreversible temperature gating in trpv1 sheds light on channel activation
Por:
Sánchez-Moreno A., Guevara-Hernández E., Contreras-Cervera R., Rangel-Yescas G., Ladrón-De-Guevara E., Rosenbaum T., Islas L.D.
Publicada:
1 ene 2018
Resumen:
Temperature-activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We have carefully characterized the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 channels is a consequence of the heat absorption process that leads to channel opening. © Sánchez-Moreno et al.
Filiaciones:
Sánchez-Moreno A.:
Departamento de Fisiología, Facultad de Medicina, México City, Mexico
Guevara-Hernández E.:
Departamento de Fisiología, Facultad de Medicina, México City, Mexico
Instituto de Fisiología Celular, México City, Mexico
Contreras-Cervera R.:
Instituto de Fisiología Celular, México City, Mexico
Rangel-Yescas G.:
Departamento de Fisiología, Facultad de Medicina, México City, Mexico
Ladrón-De-Guevara E.:
Departamento de Fisiología, Facultad de Medicina, México City, Mexico
Rosenbaum T.:
Instituto de Fisiología Celular, México City, Mexico
Islas L.D.:
Departamento de Fisiología, Facultad de Medicina, México City, Mexico
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