Activation of D1 dopamine receptors stimulates the release of GABA in the basal ganglia of the rat
Por:
Floran B., Aceves J., Sierra A., Martinez-Fong D.
Publicada:
1 ene 1990
Resumen:
Here we have explored whether dopamine is able to modulate the release of ?-aminobutyric acid (GABA) from striatal terminals to substantia nigra pars reticulata, entopeduncular nucleus, globus pallidus and caudate-putamen. The type of dopamine receptors involved was assessed by the blocking effect of either SCH 23390 (D1 antagonist) or (-)-sulpiride (D2 antagonist) of the dopamine effect. Dopamine stimulated (EC50 3.2 µM) the depolarization-induced release of [3H]GABA from slices isolated from all of the above mentioned nuclei. SCH 23390 dose-dependently blocked the dopamine stimulation, but (-)-sulpiride did not show any blocking effect. The results suggest that dopamine via D1 receptors modulates the release of GABA from striatal GABAergic terminals. © 1990.
Filiaciones:
Floran B.:
Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados, Instituto Politecnico Nacional, Mexico, D.F., Mexico
Aceves J.:
Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados, Instituto Politecnico Nacional, Mexico, D.F., Mexico
Sierra A.:
Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados, Instituto Politecnico Nacional, Mexico, D.F., Mexico
Martinez-Fong D.:
Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados, Instituto Politecnico Nacional, Mexico, D.F., Mexico
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