Relationship between serum leptin levels and weight gain in girls with central precocious puberty at 1-year follow-up
Por:
Zurita-Cruz J.N., Villasís-Keever M.A., Damasio-Santana L., Manuel-Apolinar L., Nishimura-Meguro E., Rivera-Hernández A.D.J., Garrido-Magaña E., Gutierrez-Gonzalez A., Poblano-Alcalá A.
Publicada:
1 ene 2017
Resumen:
Objective: Patients with central precocious puberty (CPP) may have increased serum leptin levels; however, it is not well known whether this increase differs between patients with and without obesity. Our objectives were to describe the changes in serum leptin in girls with CPP in the first 12 months after diagnosis based on body mass index (BMI) and to explore whether serum leptin level at CPP diagnosis is related to BMI z-score (BMIz) after a 1-year follow-up. Methods: A prospective cohort study was performed. We included 42 girls with idiopathic CPP in Tanner stages II and III. Anthropometric measurements were performed, and serum leptin was measured at study initiation and after 12 months. Patients were stratified according to BMI category (30 with a BMI in the <94th percentile and 12 with a BMI in the >95th percentile). Study variables were compared. Correlations among leptin, BMIz, and body fat were assessed. Results: Leptin increased gradually during the first year of treatment. In girls with a BMI in the <94th percentile at diagnosis, body fat percentage increased gradually during the first year of follow-up. Conclusion: Girls with a BMI in the <94th percentile have a greater risk of weight increase. Leptin level >10.5 ng/dL at diagnosis is a risk factor for weight gain after 1 year. © 2017 AACE.
Filiaciones:
Zurita-Cruz J.N.:
Unit of Medical Research in Clinical Epidemiology, National Medical Center XXI Century, Mexican Institute of Social Security, Mexico
Area Support Clinical Research from Hospital Infantil de M'xico Federico G'mez, Ministry of Health (SSA), Mexico City, Mexico
Calle Dr. M'rquez No. 162, Col. Doctores, M'xico DF, Mexico
Villasís-Keever M.A.:
Unit of Medical Research in Clinical Epidemiology, National Medical Center XXI Century, Mexican Institute of Social Security, Mexico
Damasio-Santana L.:
Area Support Clinical Research from Hospital Infantil de M'xico Federico G'mez, Ministry of Health (SSA), Mexico City, Mexico
Manuel-Apolinar L.:
Department of Endocrinology Research, Hospital of Medical Specialties, National Medical Center XXI Century, Mexican Institute of Social Security, Mexico
Nishimura-Meguro E.:
Department of Pediatric Endocrinology, Children's Hospital, National Medical Center XXI Century, Mexican Institute of Social Security, Mexico
Rivera-Hernández A.D.J.:
Department of Pediatric Endocrinology, Children's Hospital, National Medical Center XXI Century, Mexican Institute of Social Security, Mexico
Garrido-Magaña E.:
Department of Pediatric Endocrinology, Children's Hospital, National Medical Center XXI Century, Mexican Institute of Social Security, Mexico
Gutierrez-Gonzalez A.:
Arsenal Nutrition, Mexico City, Mexico
Poblano-Alcalá A.:
Arsenal Nutrition, Mexico City, Mexico
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