Increased transforming growth factor-ß1 modulates glutamate receptor expression in the hippocampus
Por:
Bae J.J., Xiang Y.-Y., Martinez-Canabal A., Frankland P.W., Yang B.B., Lu W.-Y.
Publicada:
1 ene 2011
Resumen:
Transforming growth factor-beta 1 (TGF-ß1) is an inflammation-related cytokine. Its expression in the brain increases under conditions of neurodegenerative diseases and injuries. Previous studies have shown that genomic alterations of TGF-ß1 expression in the brain cause neurodegenerative changes in aged mice. The present study revealed that increased production of TGF-ß1 in transgenic mice resulted in gliosis at young ages. In addition, the increased TGF-ß1 augmented the expression of some key subunits of a-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors in the hippocampus. Treatment of cultured hippocampal neurons with TGF-ß1 facilitated neurite outgrowth and enhanced glutamate-evoked currents. Together, these data suggest that increased TGF-ß1 alters ionotropic glutamate receptor expression and function in the hippocampus.
Filiaciones:
Bae J.J.:
Department of Anesthesia, University of Toronto, Toronto, ON, Canada
Department of Physiology, University of Toronto, Toronto, ON, Canada
Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Xiang Y.-Y.:
Molecular Brain Research Group, Robarts Research Institute, University of Western Ontario, 100 Perth Drive, London, ON N6A 5K8, Canada
Department of Anesthesia, University of Toronto, Toronto, ON, Canada
Martinez-Canabal A.:
Department of Physiology, University of Toronto, Toronto, ON, Canada
Institute of Medical Science, University of Toronto, Toronto, ON, Canada
Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada
Frankland P.W.:
Department of Physiology, University of Toronto, Toronto, ON, Canada
Institute of Medical Science, University of Toronto, Toronto, ON, Canada
Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada
Yang B.B.:
Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Lu W.-Y.:
Molecular Brain Research Group, Robarts Research Institute, University of Western Ontario, 100 Perth Drive, London, ON N6A 5K8, Canada
Department of Anesthesia, University of Toronto, Toronto, ON, Canada
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