Risk factors for steroid diabetes in rheumatic patients
Por:
Ariza-Andraca C.R., Barile-Fabris L.A., Frati-Munari A.C., Baltazar-Montufar P.
Publicada:
1 ene 1998
Resumen:
Background: Steroid induced diabetes (SDM) has been known for a long time, but its pathophysiological mechanisms as well as its predisposing factors remain unknown. Methods: In order to investigate the different factors related to the development of steroid diabetes (SDM) in patients with rheumatic diseases, we studied 27 patients with SDM, and 27 age- and sex-matched controls who also received therapy with glucocorticoids. In every case, family history of DM, body mass index, associated treatment, steroid dose and treatment duration were studied; fasting serum insulin, 'C' peptide, growth hormone and glucagon levels were measured. Results: All of the patients received prednisone. Cumulated prednisone dose was the only factor significantly associated with the development of SDM. Patients with SDM had a cumulated dose of 26.6 ± 28 g (M ± SD), while the control group received 11.6 ± 11 g (p < 0.02) (odds ratio, 6.35). Serum insulin levels were not significantly different, but insulin/glucose ratio was lower in SDM (0.104 ± 0.05) than in the control group (0.163 ± 0.07) (p < 0.05). Conclusions: These findings suggest that high cumulated prednisone dose may induce DM regardless of another hereditary or personal predisposing factor.
Filiaciones:
Ariza-Andraca C.R.:
Department of Internal Medicine, Hospital de Especialidades, Centro Medico 'La Raza', Seris y Zaachila s-n, Col. 'La Raza', 02990 Mexico DF, Mexico
Barile-Fabris L.A.:
Department of Internal Medicine, Hospital de Especialidades, Centro Medico 'La Raza', Seris y Zaachila s-n, Col. 'La Raza', 02990 Mexico DF, Mexico
Frati-Munari A.C.:
Department of Internal Medicine, Hospital de Especialidades, Centro Medico 'La Raza', Seris y Zaachila s-n, Col. 'La Raza', 02990 Mexico DF, Mexico
Baltazar-Montufar P.:
Department of Internal Medicine, Hospital de Especialidades, Centro Medico 'La Raza', Seris y Zaachila s-n, Col. 'La Raza', 02990 Mexico DF, Mexico
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