Relevance of Alternative Routes of Kynurenic Acid Production in the Brain
Por:
Ramos-Chavez, L. A., Lugo Huitron, R., Gonzalez Esquivel, D., Pineda, B., Rios, C., Silva-Adaya, D., Sanchez-Chapul, L., Roldan-Roldan, G., Perez de la Cruz, V.
Publicada:
1 ene 2018
Resumen:
The catabolism of tryptophan has gained great importance in recent years
due to the fact that the metabolites produced during this process, with
neuroactive and redox properties, are involved in physiological and
pathological events. One of these metabolites is kynurenic acid (KYNA),
which is considered as a neuromodulator since it can interact with NMDA,
nicotinic, and GPR35 receptors among others, modulating the release of
neurotransmitters as glutamate, dopamine, and acetylcholine.
Kynureninate production is attributed to kynurenine aminotransferases.
However, in some physiological and pathological conditions, its high
production cannot be explained just with kynurenine aminotransferases.
This review focuses on the alternative mechanism whereby KYNA can be
produced, either from D-amino acids or by means of other enzymes as
D-amino acid oxidase or by the participation of free radicals. It is
important to mention that an increase in KYNA levels in processes as
brain development, aging, neurodegenerative diseases, and psychiatric
disorders, which share common factors as oxidative stress, inflammation,
immune response activation, and participation of gut microbiota that can
also be related with the alternative routes of KYNA production, has been
observed.
Filiaciones:
Ramos-Chavez, L. A.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Lab Neurobiol Conducta, Mexico City, DF, Mexico
Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, SSA, Dept Neuroquim, Mexico City 14269, DF, Mexico
Lugo Huitron, R.:
Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, SSA, Dept Neuroquim, Mexico City 14269, DF, Mexico
Gonzalez Esquivel, D.:
Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, SSA, Dept Neuroquim, Mexico City 14269, DF, Mexico
Pineda, B.:
Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, SSA, Lab Neuroinmunol, Mexico City 14269, DF, Mexico
Rios, C.:
Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, SSA, Dept Neuroquim, Mexico City 14269, DF, Mexico
Silva-Adaya, D.:
Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, SSA, Lab Expt Enfermedades Neurodegenerat, Mexico City 14269, DF, Mexico
Sanchez-Chapul, L.:
Inst Nacl Rehabil, SSA, Div Neurociencias, Mexico City 14389, DF, Mexico
Roldan-Roldan, G.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Lab Neurobiol Conducta, Mexico City, DF, Mexico
Perez de la Cruz, V.:
Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, SSA, Dept Neuroquim, Mexico City 14269, DF, Mexico
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