Acetone fraction from Sechium edule (Jacq.) S.w. edible roots exhibits anti-endothelial dysfunction activity
Por:
Trejo-Moreno C., Castro-Martínez G., Méndez-Martínez M., Jiménez-Ferrer J.E., Pedraza-Chaverri J., Arrellín G., Zamilpa A., Medina-Campos O.N., Lombardo-Earl G., Barrita-Cruz G.J., Hernández B., Ramírez C.C., Santana M.A., Fragoso G., Rosas G.
Publicada:
28 jun 2018
Resumen:
Ethnopharmacological relevance: A recent ethnomedical survey on medicinal plants grown in Mexico revealed that Sechium edule (Jacq.) Sw. (Cucurbitaceae) is one of the most valued plant species to treat cardiovascular diseases, including hypertension. Fruits, young leaves, buds, stems, and tuberous roots of the plant are edible. Considering that endothelial dysfunction induced by Angiotensin II plays an important role in the pathogenesis of hypertension and is accompanied by a prooxidative condition, which in turn induces an inflammatory state, vascular remodeling, and tissue damage, and that S. edule has been reported to possess antioxidant, anti-inflammatory and antihypertensive activity, its capability to control endothelial dysfunction was also assessed. Aim of the study: To assess in vivo the anti-endothelial dysfunction activity of the acetone fraction (rSe-ACE) of the hydroalcoholic extract from S. edule roots. Materials and methods: Endothelial dysfunction was induced in female C57BL/6 J mice by a daily intraperitoneal injection of angiotensin II for 10 weeks. Either rSe-ACE or losartan (as a control) were co-administered with angiotensin II for the same period. Blood pressure was measured at weeks 0, 5, and 10. Kidney extracts were prepared to determine IL1ß, IL4, IL6, IL10, IL17, IFN?, TNFa, and TGFß levels by ELISA, along with the prooxidative status as assessed by the activity of antioxidant enzymes. The expression of ICAM-1 was evaluated by immunohistochemistry in kidney histological sections. Kidney and hepatic damage, as well as vascular tissue remodeling, were studied. Results: The rSe-ACE fraction administered at a dose of 10 mg/kg was able to control hypertension, as well as the prooxidative and proinflammatory status in kidney as efficiently as losartan, returning mice to normotensive levels. Additionally, the fraction was more efficient than losartan to prevent liver and kidney damage. Phytochemical characterization identified cinnamic acid as a major compound, and linoleic, palmitic, and myristic acids as the most abundant non-polar components in the mixture, previously reported to aid in the control of hypertension, inflammation, and oxidative stress, three important components of endothelial dysfunction. In conclusion: this study demonstrated that rSe-ACE has anti-endothelial dysfunction activity in an experimental model and highlights the role of cinnamic acid and fatty acids in the observed effects. © 2018 Elsevier B.V.
Filiaciones:
Trejo-Moreno C.:
Facultad de Medicina, Universidad Autónoma Del Estado de Morelos, Cuernavaca, Morelos, Mexico
Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos CP 62350, Mexico
Castro-Martínez G.:
Facultad de Medicina, Universidad Autónoma Del Estado de Morelos, Cuernavaca, Morelos, Mexico
Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos CP 62350, Mexico
Méndez-Martínez M.:
Facultad de Medicina, Universidad Autónoma Del Estado de Morelos, Cuernavaca, Morelos, Mexico
Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos CP 62350, Mexico
Jiménez-Ferrer J.E.:
Laboratorio de Farmacología, Centro de Investigaciones Biomédicas del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, Mexico
Laboratorio de Farmacología, Centro de Investigaciones Biomédicas del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos CP 62790, Mexico
Pedraza-Chaverri J.:
Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México, Mexico
Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México CP 04510, Mexico
Arrellín G.:
Facultad de Medicina, Universidad Autónoma Del Estado de Morelos, Cuernavaca, Morelos, Mexico
Facultad de Ciencias de la Salud, Universidad PanamericanaCiudad de México, Mexico
Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos CP 62350, Mexico
Facultad de Ciencias de la Salud, Universidad PanamericanaCiudad de México CP 03920, Mexico
Zamilpa A.:
Laboratorio de Farmacología, Centro de Investigaciones Biomédicas del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, Mexico
Laboratorio de Farmacología, Centro de Investigaciones Biomédicas del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos CP 62790, Mexico
Medina-Campos O.N.:
Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México, Mexico
Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México CP 04510, Mexico
Lombardo-Earl G.:
Laboratorio de Farmacología, Centro de Investigaciones Biomédicas del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, Mexico
Laboratorio de Farmacología, Centro de Investigaciones Biomédicas del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos CP 62790, Mexico
Barrita-Cruz G.J.:
Facultad de Medicina, Universidad Autónoma Del Estado de Morelos, Cuernavaca, Morelos, Mexico
Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos CP 62350, Mexico
Hernández B.:
Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México, Mexico
Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México CP 04510, Mexico
Ramírez C.C.:
Facultad de Medicina, Universidad Autónoma Del Estado de Morelos, Cuernavaca, Morelos, Mexico
Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos CP 62350, Mexico
Santana M.A.:
Centro de Investigación en Dinámica Celular, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Chamilpa, Cuernavaca, Morelos, Mexico
Centro de Investigación en Dinámica Celular, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Chamilpa, Cuernavaca, Morelos CP 62209, Mexico
Fragoso G.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México, Mexico
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México CP 04510, Mexico
Rosas G.:
Facultad de Medicina, Universidad Autónoma Del Estado de Morelos, Cuernavaca, Morelos, Mexico
Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos CP 62350, Mexico
|