Genetic polymorphisms of the tumor necrosis factor and lymphotoxin alpha in type 2 diabetes.
Por:
García-Elorriaga G., Mendoza-Aguilar M., del Rey-Pineda G., González-Bonilla C.
Publicada:
1 ene 2013
Categoría:
Medicine (miscellaneous)
Resumen:
To investigate the frequency of the single-base change polymorphic variants identified in tumor necrosis factor (TNF) gene (-308 G/A) and lymphotoxin alpha (LTA) (+252 G/A) in patients with type 2 diabetes (T2D). A prospective study in a Mexican-mestizo population of 51 patients with T2D and 48 healthy subjects was carried out. We took a peripheral blood sample from each individual for identification of the polymorphic genotypes by polymerase chain reaction. The genotype distribution in T2D was: TNF alpha homozygous 0%; TNFG/A heterozygous 20%; TNFG homozygous 80%. In regards to the TNF -308 G/A genotype, we found a significant difference (p = 0.012) with a bigger frequency in the group of patients. The health controls showed a higher frequency of TNF -308 G/G genotype (p = 0.034).
Filiaciones:
García-Elorriaga G.:
Unidad de Investigación Médica en Immunología e Infectología, Hospital de Infectología, Centro Médico Nacional La Raza (CMNR), Instituto Mexican del Seguro Social (IMSS), Mexico City, Mexico
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