Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy
Por:
Mancheno-Valencia A., Bologna-Molina R.E., Toussaint-Caire S., Vega-Memije M.E., Cuevas-González J.C.
Publicada:
1 ene 2018
Resumen:
Actinic prurigo (AP) is an idiopathic photodermatosis; the initial manifestations usually occur during the first decades of life but can appear at any age. Cases are usually diagnosed late once the lesions have exacerbated; due to the extensive involvement of the vermilion border and the etiology, it has been confused with and related to a potentially malignant process. Syndecan-1 and E-cadherin were positive in the epidermis, with moderate-to-intense staining in 100% of samples. Ki67 and MCM3 were expressed in the lower third of the epidermis and showed greater immunolabeling in samples that contained lymphoid follicles (Ki 67: epidermis [17.7% ± 6.79%] and dermis [7.73% ± 6.69%]; MCM3: epidermis [22.92% ± 10.12%] and dermis [6.13% ± 6.27%]). In conclusión AP is a disease in which there is no evidence that the lesions are potentially cancerous. AP cheilitis should not be confused with actinic cheilitis because they are separate entities. © 2018 Medknow Publications. All rights reserved.
Filiaciones:
Mancheno-Valencia A.:
Department of Dermatology, Dr. Manuel Gea González' General Hospital, Sección XVI, Calzada De Tlalpan 4800, Delegación Tlalpan México, D.F. C.P, Mexico
Bologna-Molina R.E.:
Faculty of Dentistry, University of the Republic, Montevideo, Uruguay
Toussaint-Caire S.:
Department of Dermatology, Dr. Manuel Gea González' General Hospital, Sección XVI, Calzada De Tlalpan 4800, Delegación Tlalpan México, D.F. C.P, Mexico
Vega-Memije M.E.:
Department of Dermatology, Dr. Manuel Gea González' General Hospital, Sección XVI, Calzada De Tlalpan 4800, Delegación Tlalpan México, D.F. C.P, Mexico
Cuevas-González J.C.:
Department of Stomatology, Institute of Biomedical Sciences, Autonomous University of Ciudad Juarez, Chihuahua, Mexico
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