Weight loss induced by 6-month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents
Por:
Huang F., Del-Río-Navarro B.E., de Castro G.T.M., Alcántara S.T., Sienra Monge J.J.L., Ontiveros J.A.P., Olivos E.N., Barron M.F., Lopéz A.R., Villafaña S., Hong E.
Publicada:
1 ene 2011
Resumen:
Background Adolescent obesity is associated with an increased risk of adult obesity and subsequent cardiovascular diseases. The present study aimed to assess the effect of weight loss after 6-month lifestyle intervention in obese adolescents on biomarkers of endothelial activation and fibrinolytic system. Methods Eighty-five obese adolescents aged 10 to 16 years were assigned to a 6-month lifestyle intervention and 61 completed the programme. We examined the effect of the intervention on adhesion molecules (selectin E, soluble intercellular adhesion molecule 1 and soluble vascular adhesion molecule 1) and fibrinolytic parameters [plasminogen activator inhibitor-1 (PAI-1) and fibrinogen]. Thirty-six lean adolescents were studied only at baseline as a comparison group. Results Compared with lean participants, obese adolescents at baseline demonstrated significantly higher levels of triglycerides, glucose, insulin, homeostasis model assessment, soluble intercellular adhesion molecule 1, PAI-1 and fibrinogen. After 6-month lifestyle intervention, those obese adolescents with decreased standard deviation score-body mass index (SDS-BMI) displayed significant decreases in insulin (19.2 ± 11.2 vs. 26.8 ± 13.2mU/L, P= 0.01), homeostasis model assessment (4.24 ± 3.19 vs. 6.58 ± 4.08, P= 0.01), selectin E (100.2 ± 60.9 vs. 116.0 ± 69.0ng/mL, P= 0.01) and PAI-1 (39.6 ± 38.0 vs. 51.8 ± 25.6ng/mL, P= 0.05) with respect to the baseline levels. No changes in these parameters were observed in the obese adolescents with stable or increased SDS-BMI. The changes of triglycerides after intervention in subgroup with decreased SDS-BMI were significantly greater than those in subgroup with stable SDS-BMI. Conclusions The present study demonstrated increased endothelial activation and impairment of the fibrinolytic system in early life, which is in part reversible by a 6-month lifestyle intervention. © 2010 Blackwell Publishing Ltd.
Filiaciones:
Huang F.:
Department of Pharmacology and Toxicology, Hospital Infántil de México Federico Gómez (HIMFG), Mexico
Del-Río-Navarro B.E.:
Department of Allergy, HIMFG, Mexico
de Castro G.T.M.:
Department of Nutrition, HIMFG, Mexico
Alcántara S.T.:
Department of Immunology, HIMFG, Mexico
Sienra Monge J.J.L.:
Department of Allergy, HIMFG, Mexico
Ontiveros J.A.P.:
Department of Pharmacology and Toxicology, Hospital Infántil de México Federico Gómez (HIMFG), Mexico
Olivos E.N.:
Department of Environmental Health, Instituto Nacional de Salud Pública, Mexico
Barron M.F.:
Department of Endocrinology, HIMFG, Mexico
Lopéz A.R.:
Division of Clinical Research, HIMFG, Mexico
Villafaña S.:
Sección de Posgrado, Escuela Superior de Medicina Del Instituto Politécnico Nacional, Mexico
Hong E.:
Department of Pharmacobiology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
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