Tau Phosphorylation in Female Neurodegeneration: Role of Estrogens, Progesterone, and Prolactin
Por:
Munoz-Mayorga, Daniel, Guerra-Araiza, Christian, Torner, Luz, Morales, Teresa
Publicada:
28 mar 2018
Categoría:
Endocrinology, diabetes and metabolism
Resumen:
Sex differences are important to consider when studying different
psychiatric, neuro-developmental, and neurodegenerative disorders,
including Alzheimer's disease (AD). These disorders can be affected by
dimorphic changes in the central nervous system and be influenced by
sex-specific hormones and neuroactive steroids. In fact, AD is more
prevalent in women than in men. One of the main characteristics of AD is
the formation of neurofibrillary tangles, composed of the phosphoprotein
Tau, and neuronal loss in specific brain regions. The scope of this work
is to review the existing evidence on how a set of hormones (estrogen,
progesterone, and prolactin) affect tau phosphorylation in the brain of
females under both physiological and pathological conditions.
Filiaciones:
Munoz-Mayorga, Daniel:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Celular & Mol, Queretaro, Mexico
Guerra-Araiza, Christian:
Hosp Especialidades Ctr Med La Raza, Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Unidad Invest Med Farmacol, Mexico City, DF, Mexico
Torner, Luz:
Inst Mexicano Seguro Social, Ctr Invest Biomed Michoacan, Morelia, Michoacan, Mexico
Morales, Teresa:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Celular & Mol, Queretaro, Mexico
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