pMEX01, a 70 kb plasmid isolated from Escherichia coli that confers resistance to multiple beta-lactam antibiotics


Por: Hernandez-Flores J.L., Pérez J.C., Gutiérrez C.S., Hernández A.C., Alonso G.S., Hernández S.P., Gómez S.R., Fernández F., Loske A.M., Guillén J.C.

Publicada: 1 jul 2018 Ahead of Print: 1 ene 2018
Categoría: Microbiology

Resumen:
Multidrug-resistant microorganisms are of great concern to public health. Genetic mobile elements, such as plasmids, are among the most relevant mechanisms by which bacteria achieve this resistance. We obtained an Escherichia coli strain CM6, isolated from cattle presenting severe diarrheic symptoms in the State of Queretaro, Mexico. It was found to contain a 70 kb plasmid (pMEX01) with a high similarity to the pHK01-like plasmids that were previously identified and described in Hong Kong. Analysis of the pMEX01 sequence revealed the presence of a bla(CTX-M-14 )gene, which is responsible for conferring resistance to multiple beta-lactam antibiotics. Several genes putatively involved in the conjugative transfer were also identified on the plasmid. The strain CM6 is of high epidemiological concern because it not only displays resistance to multiple p-lactam antibiotics but also to other kinds of antibiotics. Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Microbiologia.

Filiaciones:
Hernandez-Flores J.L.:
 Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Departamento de Ingeniería Genética, Irapuato, Guanajuato, Mexico

Pérez J.C.:
 Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico

Gutiérrez C.S.:
 Universidad Autónoma de Querétaro, Facultad de Ciencias Naturales, Querétaro, Mexico

Hernández A.C.:
 Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico

Alonso G.S.:
 Universidad Autónoma de Querétaro, Facultad de Ciencias Naturales, Querétaro, Mexico

Hernández S.P.:
 Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico

Gómez S.R.:
 Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico

Fernández F.:
 Universidad Nacional Autónoma de México, Centro de Física Aplicada y Tecnología Avanzada, Querétaro, Mexico

Loske A.M.:
 Universidad Nacional Autónoma de México, Centro de Física Aplicada y Tecnología Avanzada, Querétaro, Mexico

Guillén J.C.:
 Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico
ISSN: 15178382
Editorial
SOC BRASILEIRA MICROBIOLOGIA, AV PROF LINEU PRESTES,1374, 05508 SAO PAULO, BRAZIL, Brasil
Tipo de documento: Article
Volumen: 49 Número: 3
Páginas: 569-574
WOS Id: 000441165500016
ID de PubMed: 29449172