Neural mechanism of exercise: Neurovascular responses to exercise
Por:
Yuan T.-F., Rocha N.B.F., Paes F., Arias-Carrión O., Machado S., De Sá Filho A.S.
Publicada:
1 ene 2015
Resumen:
Physical exercise is responsible for different metabolic and hemodynamic changes, including increased cerebral blood flow and perfusion. It is known that running increases vascular endothelial growth factor expression in the brain, which is critical for the anti-depressive effects of adult neurogenesis induced by physical exercise. Both animal and human studies revealed that neurovascular responses to physical exercise are well correlated to adult hippocampal neurogenesis and cognition improvement. Yet it is unknown if the increased blood perfusion to hippocampus is affecting the adult neurogenesis. Manipulating systemic blood pressure, or stimulating the cerebral blood flow with alternative measures, might provide useful tools to understand how much neurovascular plasticity contributes to the brain cognition enhancement by physical exercise. In addition, it will be interesting to examine the responses of brain cells (including neuron, glia and endothelia cells) to increased shear stress and oxygen load, to investigate the underlying molecular mechanisms. © 2015 Bentham Science Publishers.
Filiaciones:
Yuan T.-F.:
School of Psychology, Nanjing Normal University, Nanjing, China
Rocha N.B.F.:
Polytechnic Institute of Porto, School of Accounting and Administration, Porto, Portugal
Paes F.:
Laboratory of Panic and Respiration, Institute de Psychiatry, Federal University of Rio de Janeiro, Brazil
Arias-Carrión O.:
Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General Dr. Manuel Gea González/IFC-UNAM, Mexico City, Mexico
Machado S.:
Laboratory of Panic and Respiration, Institute de Psychiatry, Federal University of Rio de Janeiro, Brazil
Physical Activity Neuroscience, Salgado de Oliveira University, Niterói, Brazil
De Sá Filho A.S.:
Laboratory of Panic and Respiration, Institute de Psychiatry, Federal University of Rio de Janeiro, Brazil
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