Differential requirement of de novo Arc protein synthesis in the insular cortex and the amygdala for safe and aversive taste long-term memory formation
Por:
Guzmán-Ramos K., Venkataraman A., Morin J.-P., Osorio-Gómez D., Bermúdez-Rattoni F.
Publicada:
16 abr 2018
Categoría:
Behavioral neuroscience
Resumen:
Several immediate early genes products are known to be involved in the
facilitation of structural and functional modifications at distinct
synapses activated through experience. The IEG-encoded protein Arc
(activity regulated cytoskeletal-associated protein) has been widely
implicated in long-term memory formation and stabilization. In this
study, we sought to evaluate a possible role for de novo Arc protein
synthesis in the insular cortex (IC) and in the amygdala (AMY) during
long-term taste memory formation. We found that acute inhibition of Arc
protein synthesis through the infusion of antisense oligonucleotides
administered in the IC before a novel taste presentation, affected
consolidation of a safe taste memory trace (ST) but spared consolidation
of conditioned taste aversion (CTA). Conversely, blocking Arc synthesis
within the AMY impaired CTA consolidation but had no effect on ST
long-term memory formation. Our results suggest that Arc-dependent
plasticity during taste learning is required within distinct structures
of the medial temporal lobe, depending on the emotional valence of the
memory trace.
Filiaciones:
Guzmán-Ramos K.:
Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Unidad Lerma, Av. De las Garzas No. 10, Col. El Panteón, Lerma de Villada, Estado de México, Mexico
Venkataraman A.:
Department of Biology, Texas A&M University, College Station, TX, United States
Morin J.-P.:
Departamento de Fisiología, Facultad de Medicina, UniversidadNacional Autónoma de México, Apartado Postal 70-253, México D.F., Mexico
Osorio-Gómez D.:
Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Unidad Lerma, Av. De las Garzas No. 10, Col. El Panteón, Lerma de Villada, Estado de México, Mexico
Departamento de Neurociencias, Instituto de Fisiologia Celular, Mexico
Bermúdez-Rattoni F.:
Departamento de Neurociencias, Instituto de Fisiologia Celular, Mexico
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