Oseltamivir and indomethacin reduce the oxidative stress in brain and stomach of infected rats
Por:
Guzmán D.C., Herrera M.O., Brizuela N.O., Mejía G.B., García E.H., Olguín H.J., Ruíz N.L., Peraza A.V.
Publicada:
1 feb 2018
Resumen:
The aim of this study was to determine the effect of oseltamivir and
indomethacin on lipid peroxidation (LP), GABA levels, and ATPase
activity in brain and stomach of normal and infected rats (IR), as novel
inflammation model. Female Sprague Dawley rats grouped five each, either
in the absence or presence of a live culture of Salmonella typhimurium
(S. typh), were treated as follows: group 1 (control), PBS buffer; group
2, oseltamivir (100 mg/kg); group 3, indomethacin (67 mu g/rat); group
4, oseltamivir (100 mg/kg) + indomethacin (67 g/rat). All drugs were
given intraperitoneally for 5days. IR received the same treatments and
the brain and stomach of the rats were removed in order to measure
levels of GABA, LP, and total ATPase, using validated methods. Levels of
GABA increased in stomach and cortex of IR with oseltamivir, but
decreased in striatum and cerebellum/medulla oblongata of IR with
indomethacin. LP decreased in the three brain regions of IR with
oseltamivir. ATPase increased in stomach of IR and non-IR with
oseltamivir and in striatum and cerebellum/medulla oblongata of IR with
indomethacin. Results suggest that the effect of free radicals produced
in an infection and inflammatory condition caused by S.typh could be
less toxic by a combination of oseltamivir and indomethacin.
Filiaciones:
Guzmán D.C.:
Laboratorio de Neurociencias Instituto Nacional de Pediatría (INP) Mexico Mexico
Herrera M.O.:
Laboratorio de Bacteriología Experimental INP SSA Mexico
Brizuela N.O.:
Laboratorio de Neurociencias Instituto Nacional de Pediatría (INP) Mexico Mexico
Mejía G.B.:
Laboratorio de Neurociencias Instituto Nacional de Pediatría (INP) Mexico Mexico
García E.H.:
Laboratorio de Farmacología Facultad de Medicina INP Universidad Nacional Autónoma de Mexico Mexico
Olguín H.J.:
Laboratorio de Farmacología Facultad de Medicina INP Universidad Nacional Autónoma de Mexico Mexico
Ruíz N.L.:
Laboratorio de Neurociencias Instituto Nacional de Pediatría (INP) Mexico Mexico
Peraza A.V.:
Laboratorio de Neurociencias Instituto Nacional de Pediatría (INP) Mexico Mexico
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