Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development
Por:
Anahi Valdes-Rives, Silvia, Gonzalez-Arenas, Aliesha
Publicada:
1 ene 2017
Resumen:
Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. Many ongoing studies aim to understand ATX-LPA axis signaling in cancer and its potential as a therapeutic target. In this review, we discuss the evidence linking LPA signaling to cancer-related inflammation and its impact on cancer progression. © 2017 Silvia Anahi Valdés-Rives and Aliesha González-Arenas.
Filiaciones:
Anahi Valdes-Rives, Silvia:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Ciudad Univ, Ciudad De Mexico 04510, Mexico
Gonzalez-Arenas, Aliesha:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Ciudad Univ, Ciudad De Mexico 04510, Mexico
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