A Fatty Acids Mixture Reduces Anxiety-Like Behaviors in Infant Rats Mediated by GABA(A) Receptors
Por:
Bernal-Morales, Blandina, Cueto-Escobedo, Jonathan, Guillen-Ruiz, Gabriel, Rodriguez-Landa, Juan F., Contreras, Carlos M.
Publicada:
1 ene 2017
Resumen:
Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and
maternal milk reduce behavioral indicators of experimental anxiety in
adult Wistar rats. Unknown, however, is whether the anxiolytic-like
effects of fatty acids provide a natural mechanism against anxiety in
young offspring. The present study assessed the anxiolytic-like effect
of a mixture of lauric acid, myristic acid, palmitic acid, palmitoleic
acid, stearic acid, oleic acid, elaidic acid, and linoleic acid in
Wistar rats on postnatal day 28. Infant rats were subjected to the
elevated plus maze, defensive burying test, and locomotor activity test.
Diazepam was used as a reference anxiolytic drug. A group that was
pretreated with picrotoxin was used to explore the participation of
gamma-aminobutyric acid-A (GABAA) receptors in the anxiolytic-like
effects. Similar to diazepam, the fatty acid mixture significantly
increased the frequency of entries into and time spent on the open arms
of the elevated plus maze and decreased burying behavior in the
defensive burying test, without producing significant changes in
spontaneous locomotor activity. These anxiolytic-like effects were
blocked by picrotoxin. Results suggest that these fatty acids that are
contained in maternal fluid may reduce anxiety-like behavior by
modulating GABAergic neurotransmission in infant 28-day-old rats.
Filiaciones:
Bernal-Morales, Blandina:
Univ Veracruzana, Inst Neuroetol, Lab Neurofarmacol, Xalapa 91190, Ver, Mexico
Cueto-Escobedo, Jonathan:
Univ Veracruzana, Inst Neuroetol, Lab Neurofarmacol, Xalapa 91190, Ver, Mexico
Guillen-Ruiz, Gabriel:
Univ Veracruzana, Inst Neuroetol, Lab Neurofarmacol, Xalapa 91190, Ver, Mexico
Rodriguez-Landa, Juan F.:
Univ Veracruzana, Inst Neuroetol, Lab Neurofarmacol, Xalapa 91190, Ver, Mexico
Contreras, Carlos M.:
Univ Veracruzana, Inst Neuroetol, Lab Neurofarmacol, Xalapa 91190, Ver, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Unidad Perifer Xalapa, Xalapa 91190, Ver, Mexico
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