Integrated view of Vibrio cholerae in the Americas
Por:
Domman, Daryl, Quilici, Marie-Laure, Dorman, Matthew J., Njamkepo, Elisabeth, Mutreja, Ankur, Mather, Alison E., Delgado, Gabriella, Morales-Espinosa, Rosario, Grimont, Patrick A. D., Leonardo Lizarraga-Partida, Marcial, Bouchier, Christiane, Aanensen, David M., Kuri-Morales, Pablo, Tarr, Cheryl L., Dougan, Gordon, Parkhill, Julian, Campos, Josefina, Cravioto, Alejandro, Weill, Francois-Xavier, Thomson, Nicholas R.
Publicada:
10 nov 2017
Resumen:
Latin America has experienced two of the largest cholera epidemics in modern history; one in 1991 and the other in 2010. However, confusion still surrounds the relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial populations. We used whole-genome sequencing to characterize cholera across the Americas over a 40-year time span. We found that both epidemics were the result of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least seven lineages local to the Americas are associated with disease that differs epidemiologically from epidemic cholera. Our results consolidate historical accounts of pandemic cholera with data to show the importance of local lineages, presenting an integrated view of cholera that is important to the design of future disease control strategies. © 2017, American Association for the Advancement of Science. All rights reserved.
Filiaciones:
Domman, Daryl:
Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England
Quilici, Marie-Laure:
Inst Pasteur, Unite Bacteries Pathogenes Enter, F-75015 Paris, France
Dorman, Matthew J.:
Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England
Njamkepo, Elisabeth:
Inst Pasteur, Unite Bacteries Pathogenes Enter, F-75015 Paris, France
Mutreja, Ankur:
Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England
Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 0SP, England
Mather, Alison E.:
Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England
Univ Cambridge, Dept Vet Med, Madingley Rd, Cambridge CB3 0ES, England
Delgado, Gabriella:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City, DF, Mexico
Morales-Espinosa, Rosario:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City, DF, Mexico
Grimont, Patrick A. D.:
Inst Pasteur, Unite Biodivers Bacteries Pathogenes Emergentes, F-75015 Paris, France
Leonardo Lizarraga-Partida, Marcial:
CICESE, Ensenada, Baja California, Mexico
Bouchier, Christiane:
Inst Pasteur, Plate Forme Genom PF1, F-75015 Paris, France
Aanensen, David M.:
Ctr Genom Pathogen Surveillance, Wellcome Genome Campus, Cambridge CB10 1SA, England
Kuri-Morales, Pablo:
Secretaria Salud Mexico, Subsecretaria Prevenc & Promoc Salud, Mexico City, DF, Mexico
Tarr, Cheryl L.:
Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA USA
Dougan, Gordon:
Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England
Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 0SP, England
Parkhill, Julian:
Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England
Campos, Josefina:
ANLIS, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina
Cravioto, Alejandro:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City, DF, Mexico
Weill, Francois-Xavier:
Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England
Inst Pasteur, Unite Bacteries Pathogenes Enter, F-75015 Paris, France
Thomson, Nicholas R.:
Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England
London Sch Hyg & Trop Med, London WC1E 7HT, England
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