Molecular characterization of atypical antigenic variants of canine rabies virus reveals its reintroduction by wildlife vectors in southeastern Mexico
Por:
Garces-Ayala, Fabiola, Arechiga-Ceballos, Nidia, Ortiz-Alcantara, Joanna M., Gonzalez-Duran, Elizabeth, Perez-Agueros, Sandra I., Mendez-Tenorio, Alfonso, Torres-Longoria, Belem, Lopez-Martinez, Irma, Hernandez-Rivas, Lucia, Alberto Diaz-Quinonez, Jose, Ernesto Ramirez-Gonzalez, Jose
Publicada:
1 dic 2017
Resumen:
Rabies is an infectious viral disease that is practically always fatal
following the onset of clinical signs. In Mexico, the last case of human
rabies transmitted by dogs was reported in 2006 and canine rabies has
declined significantly due to vaccination campaigns implemented in the
country. Here we report on the molecular characterization of six rabies
virus strains found in Yucatan and Chiapas, remarkably, four of them
showed an atypical reaction pattern when antigenic characterization with
a reduced panel of eight monoclonal antibodies was performed.
Phylogenetic analyses on the RNA sequences unveiled that the three
atypical strains from Yucatan are associated with skunks. Analysis using
the virus entire genome showed that they belong to a different lineage
distinct from the variants described for this animal species in Mexico.
The Chiapas atypical strain was grouped in a lineage that was considered
extinct, while the others are clustered within classic dog variants.
Filiaciones:
Garces-Ayala, Fabiola:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
ENCB, Inst Politecn Nacl, Prolongac Carpio & Plan Ayala S-N, Mexico City 11340, DF, Mexico
Arechiga-Ceballos, Nidia:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
Ortiz-Alcantara, Joanna M.:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
Fac Ciencias, Unidad Acad Ciencias & Tecnol UNAM, Parque Cient & Tecnol Yucatan, Merida 97302, Yucatan, Mexico
Gonzalez-Duran, Elizabeth:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
ENCB, Inst Politecn Nacl, Prolongac Carpio & Plan Ayala S-N, Mexico City 11340, DF, Mexico
Perez-Agueros, Sandra I.:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
Mendez-Tenorio, Alfonso:
ENCB, Inst Politecn Nacl, Prolongac Carpio & Plan Ayala S-N, Mexico City 11340, DF, Mexico
Torres-Longoria, Belem:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
ENCB, Inst Politecn Nacl, Prolongac Carpio & Plan Ayala S-N, Mexico City 11340, DF, Mexico
Lopez-Martinez, Irma:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
Hernandez-Rivas, Lucia:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
Alberto Diaz-Quinonez, Jose:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Paseo Fac S-N,Ciudad Univ, Mexico City 04510, DF, Mexico
Ernesto Ramirez-Gonzalez, Jose:
Inst Diagnost & Referencia Epidemiol Dr Manuel Ma, Secretaria Salud, Francisco de P Miranda 177, Mexico City 01480, DF, Mexico
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