Omics techniques and biobanks to find new biomarkers for the early detection of acute lymphoblastic leukemia in middle-income countries: a perspective from Mexico
Por:
Alejandro Aguirre-Guillen, William, Angeles-Floriano, Tania, Lopez-Martinez, Briceida, Reyes-Morales, Hortensia, Zlotnik, Albert, Valle-Rios, Ricardo
Publicada:
1 may 2017
Categoría:
Pediatrics, perinatology and child health
Resumen:
Acute lymphoblastic leukemia (ALL) affects the quality of life of many
children in the world and particularly in Mexico, where a high incidence
has been reported. With a proper financial investment and with
well-organized institutions caring for those patients, together with
solid platforms to perform high-throughput analyses, we propose the
creation of a Mexican repository system of serum and cells from bone
marrow and blood samples derived from tissues of pediatric patients with
ALL diagnosis. This resource, in combination with omics technologies,
particularly proteomics and metabolomics, would allow longitudinal
studies, offering an opportunity to design and apply personalized ALL
treatments. Importantly, it would accelerate the development of
translational science and will lead us to further discoveries, including
the identification of new biomarkers for the early detection of
leukemia. (C) 2017 Hospital Infantil de Mexico Federico Gomez. Published
by Masson Doyma Mexico S. A. This is an open access article under the CC
BY-NC-ND license.
Filiaciones:
Alejandro Aguirre-Guillen, William:
Hosp Infantil Mexico Dr Federico Gomez, Lab Invest Inmunol & Prote, Mexico City, DF, Mexico
Univ Autonoma Metropolitana, Unidad Biol & Ciencias Salud, Mexico City, DF, Mexico
Angeles-Floriano, Tania:
Hosp Infantil Mexico Dr Federico Gomez, Lab Invest Inmunol & Prote, Mexico City, DF, Mexico
Hosp Infantil Mexico Dr Federico Gomez, Dept Lab Clin, Mexico City, DF, Mexico
Lopez-Martinez, Briceida:
Hosp Infantil Mexico Dr Federico Gomez, Subdirecc Diagnost Clin, Mexico City, DF, Mexico
Reyes-Morales, Hortensia:
Hosp Infantil Mexico Dr Federico Gomez, Dept Invest, Mexico City, DF, Mexico
Zlotnik, Albert:
Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92717 USA
Univ Calif Irvine, Inst Immunol, Irvine, CA USA
Valle-Rios, Ricardo:
Hosp Infantil Mexico Dr Federico Gomez, Lab Invest Inmunol & Prote, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Unidad Invest, Escuela Med, Mexico City, DF, Mexico
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