Regulated expression of the lncRNA TERRA and its impact on telomere biology
Por:
Oliva-Rico D., Herrera L.A.
Publicada:
1 oct 2017
Resumen:
The telomere protects against genomic instability by minimizing the accelerated end resection of the genetic material, a phenomenon that results in severe chromosome instability that could favor the transformation of a cell by enabling the emergence of tumor-promoting mutations. Some mechanisms that avoid this fate, such as capping and loop formation, have been very well characterized; however, telomeric non-coding transcripts, such as long non-coding RNAs (lncRNAs), should also be considered in this context because they play roles in the organization of telomere dynamics, involving processes such as replication, degradation, extension, and heterochromatin stabilization. Although the mechanism through which the expression of telomeric transcripts regulates telomere dynamics is not yet clear, a non-coding RNA component opens the research options in telomere biology and the impact that it can have on telomere-associated diseases such as cancer. © 2017 The Authors
Filiaciones:
Oliva-Rico D.:
Univ Nacl Autonoma Mexico, Unidad Invest Biomed Canc, Inst Nacl Cancerol, Inst Invest Biomed, Mexico City, DF, Mexico
Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico
Herrera L.A.:
Univ Nacl Autonoma Mexico, Unidad Invest Biomed Canc, Inst Nacl Cancerol, Inst Invest Biomed, Mexico City, DF, Mexico
Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico
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