Relación de los mecanismos inmunológicos del asma y la contaminación ambiental
Por:
Falcón-Ro Dríguez C.I., Rosas-Pérez I., Segura-Medina P.
Publicada:
1 ene 2017
Categoría:
Medicine (miscellaneous)
Resumen:
Introduction: More than 300 million people around the world suffer from asthma, and estimations indicate that this figure will increase to 400 million by 2025 due to criteria pollutants. However, given their limitations, epidemiological studies on pollution and its role in the development of asthma are controversial. Objectives: To describe the differences and similarities of the immunological response of asthmatic patients and animal models to allergic asthma after exposure to criteria pollutants and biological elements, in order to identify the immunological factors related to the development of asthma. Materials and methods: A systematic search was conducted in asthma databases and criteria pollutants. Results: The Th2 response is activated by the inhalation of ozone, nitrogen dioxide, sulfur and acute exposure to particulate matter. On the other hand, contact with certain types of pollens and glucans and the chronic exposure of particles increases the Th1 response, which inhibits Th2 response producing a “protective effect”. Conclusions: Th1 response could cause low or no association between exposure to pollution and the development of asthma in different cities, which constitutes another limitation in epidemiological studies. © 2017, Universidad Nacional de Colombia. All rights reserved.
Filiaciones:
Falcón-Ro Dríguez C.I.:
Universidad Nacional Autónoma de México, Facultad de Medicina, Posgrado en Ciencias Biológicas, Ciudad de México, Mexico
Instituto Nacional de Enfermedades Respiratorias, Departamento de Investigación en Hiperreactividad Bronquial, Ciudad de México, Mexico
Rosas-Pérez I.:
Universidad Nacional Autónoma de México, Centro de Ciencias de la Atmósfera, Laboratorio de Aerobiología, Ciudad de México, Mexico
Segura-Medina P.:
Instituto Nacional de Enfermedades Respiratorias, Departamento de Investigación en Hiperreactividad Bronquial, Ciudad de México, Mexico
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