Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing
Por:
Romero-Hidalgo, Sandra, Ochoa-Leyva, Adrian, Garciarrubio, Alejandro, Acuna-Alonzo, Victor, Antunez-Arguelles, Erika, Balcazar-Quintero, Martha, Barquera-Lozano, Rodrigo, Carnevale, Alessandra, Cornejo-Granados, Fernanda, Carlos Fernandez-Lopez, Juan, Garcia-Herrera, Rodrigo, Garcia-Ortiz, Humberto, Granados-Silvestre, Angeles, Granados, Julio, Guerrero-Romero, Fernando, Hernandez-Lemus, Enrique, Leon-Mimila, Paola, Macin-Perez, Gaston, Martinez-Hernandez, Angelica, Menjivar, Marta, Morett, Enrique, Orozco, Lorena, Ortiz-Lopez, Guadalupe, Perez-Villatoro, Fernando, Rivera-Morales, Javier, Riveros-McKay, Fernando, Villalobos-Comparan, Marisela, Villamil-Ramirez, Hugo, Villarreal-Molina, Teresa, Canizales-Quinteros, Samuel, Soberon, Xavier
Publicada:
18 oct 2017
Resumen:
Understanding the genetic structure of Native American populations is important to clarify their diversity, demographic history, and to identify genetic factors relevant for biomedical traits. Here, we show a demographic history reconstruction from 12 Native American whole genomes belonging to six distinct ethnic groups representing the three main described genetic clusters of Mexico (Northern, Southern, and Maya). Effective population size estimates of all Native American groups remained below 2,000 individuals for up to 10,000 years ago. The proportion of missense variants predicted as damaging is higher for undescribed (~ 30%) than for previously reported variants (~ 15%). Several variants previously associated with biological traits are highly frequent in the Native American genomes. These findings suggest that the demographic and adaptive processes that occurred in these groups shaped their genetic architecture and could have implications in biological processes of the Native Americans and Mestizos of today. © 2017 The Author(s).
Filiaciones:
Romero-Hidalgo, Sandra:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Ochoa-Leyva, Adrian:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
UNAM, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
Garciarrubio, Alejandro:
UNAM, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
Acuna-Alonzo, Victor:
Escuela Nacl Antropol & Hist, Mexico City 14030, DF, Mexico
Antunez-Arguelles, Erika:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Balcazar-Quintero, Martha:
Univ Iberoamer, Direcc Formac & Acc Social, Mexico City 01298, DF, Mexico
Barquera-Lozano, Rodrigo:
Escuela Nacl Antropol & Hist, Mexico City 14030, DF, Mexico
Carnevale, Alessandra:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Cornejo-Granados, Fernanda:
UNAM, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
Carlos Fernandez-Lopez, Juan:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Garcia-Herrera, Rodrigo:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Garcia-Ortiz, Humberto:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Granados-Silvestre, Angeles:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Granados, Julio:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City 14080, DF, Mexico
Guerrero-Romero, Fernando:
Inst Mexicano Seguro Social, Unidad Invest Biomed, Durango 34067, CO, Mexico
Hernandez-Lemus, Enrique:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Leon-Mimila, Paola:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Macin-Perez, Gaston:
Escuela Nacl Antropol & Hist, Mexico City 14030, DF, Mexico
Martinez-Hernandez, Angelica:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Menjivar, Marta:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Hosp Juarez Mexico, Mexico City 07760, DF, Mexico
Morett, Enrique:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Orozco, Lorena:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Ortiz-Lopez, Guadalupe:
Hosp Juarez Mexico, Mexico City 07760, DF, Mexico
Perez-Villatoro, Fernando:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Winter Genom, Mexico City 07300, DF, Mexico
Rivera-Morales, Javier:
Escuela Nacl Antropol & Hist, Mexico City 14030, DF, Mexico
Riveros-McKay, Fernando:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Winter Genom, Mexico City 07300, DF, Mexico
Villalobos-Comparan, Marisela:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Villamil-Ramirez, Hugo:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Villarreal-Molina, Teresa:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Canizales-Quinteros, Samuel:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Soberon, Xavier:
Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico
UNAM, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
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