Relationships between structure, in vivo function and long-range axonal target of cortical pyramidal tract neurons
Por:
Rojas-Piloni, Gerardo, Guest, Jason M., Egger, Robert, Johnson, Andrew S., Sakmann, Bert, Oberlaender, Marcel
Publicada:
11 oct 2017
Resumen:
Pyramidal tract neurons (PTs) represent the major output cell type of the neocortex. To investigate principles of how the results of cortical processing are broadcasted to different downstream targets thus requires experimental approaches, which provide access to the in vivo electrophysiology of PTs, whose subcortical target regions are identified. On the example of rat barrel cortex (vS1), we illustrate that retrograde tracer injections into multiple subcortical structures allow identifying the long-range axonal targets of individual in vivo recorded PTs. Here we report that soma depth and dendritic path lengths within each cortical layer of vS1, as well as spiking patterns during both periods of ongoing activity and during sensory stimulation, reflect the respective subcortical target regions of PTs. We show that these cellular properties result in a structure-function parameter space that allows predicting a PT's subcortical target region, without the need to inject multiple retrograde tracers. © 2017 The Author(s).
Filiaciones:
Rojas-Piloni, Gerardo:
Univ Nacl Autonoma Mexico, Dept Neurobiol Desarrollo & Neurofisiol, Inst Neurobiol, Blvd Juriquilla 3001,Campus UNAM Juriquilla, Queretaro 76230, Mexico
Max Planck Florida Inst Neurosci, Digital Neuroanat, 1 Max Planck Way, Jupiter, FL 33458 USA
Guest, Jason M.:
Max Planck Florida Inst Neurosci, Digital Neuroanat, 1 Max Planck Way, Jupiter, FL 33458 USA
Ctr Adv European Studies & Res, Max Planck Grp Silico Brain Sci, Ludwig Erhard Allee 2, D-53175 Bonn, Germany
Max Planck Inst Biol Cybernet, Bernstein Grp Computat Neuroanat, Spemannstr 38-44, D-72076 Tubingen, Germany
Egger, Robert:
Max Planck Inst Biol Cybernet, Bernstein Grp Computat Neuroanat, Spemannstr 38-44, D-72076 Tubingen, Germany
Johnson, Andrew S.:
Max Planck Florida Inst Neurosci, Digital Neuroanat, 1 Max Planck Way, Jupiter, FL 33458 USA
Sakmann, Bert:
Max Planck Florida Inst Neurosci, Digital Neuroanat, 1 Max Planck Way, Jupiter, FL 33458 USA
Oberlaender, Marcel:
Max Planck Florida Inst Neurosci, Digital Neuroanat, 1 Max Planck Way, Jupiter, FL 33458 USA
Ctr Adv European Studies & Res, Max Planck Grp Silico Brain Sci, Ludwig Erhard Allee 2, D-53175 Bonn, Germany
Max Planck Inst Biol Cybernet, Bernstein Grp Computat Neuroanat, Spemannstr 38-44, D-72076 Tubingen, Germany
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