Thyroid Transcription Factor-1 Expression in Adenocarcinomas of the Bile Duct
Por:
Lino-Silva, Leonardo S., Salcedo-Hernandez, Rosa A., Garcia-Gomez, Miguel A., Ruiz-Garcia, Erika B., Aguilar-Romero, Jose M., Dominguez-Rodriguez, Jorge A., Herrera-Gomez, Angel, Maldonado-Martinez, Hector A.
Publicada:
1 feb 2016
Resumen:
Background. The immunoreactivity of thyroid transcription factor-1
(TTF-1) is a very specific marker for lung and thyroid neoplasms; the
expression of TTF-1 has also been demonstrated in extrapulmonary
carcinomas. We examined the expression of TTF-1 in 15 intestinal-type
adenocarcinomas of the extrahepatic bile duct. We then compared the
expression to TTF-1 staining with other immunohistochemical markers
including cytokeratin (CK) 7, CK20, caudal-type homeobox transcription
factor 2 (CDX2), Napsin A, and MUC2. We additionally compared the
clinicopathological prognostic factors with the TTF-1 expression status.
Results. Nuclear TTF-1 staining was detected in 2 cases (13.3%), and
Napsin A was positive in the same 2 cases (13.3%). All cases were
positive for CK20, CDX2, and MUC2; 5 cases were positive for CK7. There
was no correlation between TTF-1 expression and the clinicopathological
characteristics. Conclusions. To avoid potential pitfalls, TTF-1 should
be interpreted in conjunction with the clinical setting, histology, and
the results of markers such as CK7, CK20, Napsin A, and CDX2. This
report is the first of TTF-1 positivity in adenocarcinomas from the
extrahepatic biliary tract.
Filiaciones:
Lino-Silva, Leonardo S.:
Inst Nacl Cancerol, Mexico City 14080, DF, Mexico
Salcedo-Hernandez, Rosa A.:
Inst Nacl Cancerol, Mexico City 14080, DF, Mexico
Garcia-Gomez, Miguel A.:
Inst Nacl Cancerol, Mexico City 14080, DF, Mexico
Ruiz-Garcia, Erika B.:
Inst Nacl Cancerol, Mexico City 14080, DF, Mexico
Aguilar-Romero, Jose M.:
Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico
Dominguez-Rodriguez, Jorge A.:
Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico
Herrera-Gomez, Angel:
Inst Nacl Cancerol, Mexico City 14080, DF, Mexico
Maldonado-Martinez, Hector A.:
Inst Nacl Cancerol, Mexico City 14080, DF, Mexico
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