Neutrophil Functions in Periodontal Homeostasis
Por:
Cortes-Vieyra, Ricarda, Rosales, Carlos, Uribe-Querol, Eileen
Publicada:
1 ene 2016
Resumen:
Oral tissues are constantly exposed to damage from the mechanical effort
of eating and to microorganisms, mostly bacteria. In healthy gingiva
tissue remodeling and a balance between bacteria and innate immune cells
are maintained. However, excess of bacteria biofilm (plaque) creates an
inflammation state that recruits more immune cells, mainly neutrophils
to the gingiva. Neutrophils create a barrier for bacteria to reach
inside tissues. When neutrophils are insufficient, bacteria thrive
causing more inflammation that has been associated with systemic effects
on other conditions such as atherosclerosis, diabetes, and cancer. But
paradoxically when neutrophils persist, they can also promote a chronic
inflammatory state that leads to periodontitis, a condition that leads
to damage of the bone-supporting tissues. In periodontitis, bone loss is
a serious complication. How a neutrophil balance is needed for
maintaining healthy oral tissues is the focus of this review. We present
recent evidence on how alterations in neutrophil number and function can
lead to inflammatory bone loss, and how some oral bacteria signal
neutrophils to block their antimicrobial functions and promote an
inflammatory state. Also, based on this new information, novel
therapeutic approaches are discussed.
Filiaciones:
Cortes-Vieyra, Ricarda:
Univ Nacl Autonoma Mexico, Dept Immunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Rosales, Carlos:
Univ Nacl Autonoma Mexico, Dept Immunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Uribe-Querol, Eileen:
Univ Nacl Autonoma Mexico, Div Estudios Posgrado & Invest, Fac Odontol, Mexico City 04510, DF, Mexico
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