Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?
Por:
Lucinda Contreras-Zentella, Martha, Hernandez-Munoz, Rolando
Publicada:
1 ene 2016
Resumen:
Hepatic diseases are a major concern worldwide. Increased specific
plasma enzyme activities are considered diagnostic features for liver
diseases, since enzymes are released into the blood compartment
following the deterioration of the organ. Release of liver mitochondrial
enzymes is considered strong evidence for hepatic necrosis, which is
associated with an increased production of ROS, often leading to greater
hepatic lipid peroxidation. Lipotoxic mediators and intracellular
signals activated Kupffer cells, which provides evidence strongly
suggesting the participation of oxidant stress in acute liver damage,
inducing the progression of liver injury to chronic liver damage.
Elevated transaminase activities are considered as an index marker of
hepatotoxicity, linked to oxidant stress. However, a drastic increase of
serum activities of liver enzyme markers ought not necessarily to
reflect liver cell death. In fact, increased serum levels of cytoplasmic
enzymes have readily been observed after partial hepatectomy (PH) in the
regenerating liver of rats. In this regard, we are now showing that in
vitro modifications of the oxidant status affect differentially the
release of liver enzymes, indicating that this release is a strictly
controlled event and not directly related to the onset of oxidant stress
of the liver.
Filiaciones:
Lucinda Contreras-Zentella, Martha:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City 04510, DF, Mexico
Hernandez-Munoz, Rolando:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City 04510, DF, Mexico
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