Magnetite Nanoparticles Functionalized with Vitamin E analogues: Anticancer Effects


Por: Angulo-Molina, A., Mendez-Rojas, M. A., Palacios-Hernandez, T., Contreras-Lopeze, O. E., Hirata-Florese, G. A., Flores, J. C., Flores, K. L., Velazquez, C., Robles-Zepeda, R., Silva-Campa, E., Sarabia, A., Barboza-Flores, M., Pedroza-Montero, M., Reyes-Leyva, J. R., Hernandez, J.

Publicada: 1 ene 2016
Resumen:
Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@alpha-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@alpha-TOS protect and enhance bioactivity of alpha-TOS in vitro. Nps@alpha-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@alpha-TOS with other alternative treatments. (C) 2016 Elsevier Ltd. All rights reserved.

Filiaciones:
Angulo-Molina, A.:
 Univ Sonora UNISON, Dept Invest Fis DIFUS, Hermosillo 83000, Sonora, Mexico

 Univ Sonora UNISON, Dept Quim Biol, Hermosillo 83000, Sonora, Mexico

Mendez-Rojas, M. A.:
 Univ Americas, Puebla UDLAP, Puebla 72820, Mexico

Palacios-Hernandez, T.:
 Johns Hopkins Univ, Baltimore, MD 21218 USA

Contreras-Lopeze, O. E.:
 UNAM, CNyN, Ensenada 22860, Baja California, Mexico

Hirata-Florese, G. A.:
 UNAM, CNyN, Ensenada 22860, Baja California, Mexico

Flores, J. C.:
 IMSS, Ctr Invest Biomed Oriente CIBIOR, HGZ 5, Puebla 42730, Mexico

Flores, K. L.:
 IMSS, Ctr Invest Biomed Oriente CIBIOR, HGZ 5, Puebla 42730, Mexico

Velazquez, C.:
 Univ Sonora UNISON, Dept Quim Biol, Hermosillo 83000, Sonora, Mexico

Robles-Zepeda, R.:
 Univ Sonora UNISON, Dept Quim Biol, Hermosillo 83000, Sonora, Mexico

Silva-Campa, E.:
 Univ Sonora UNISON, Dept Invest Fis DIFUS, Hermosillo 83000, Sonora, Mexico

Sarabia, A.:
 Univ Sonora UNISON, Dept Invest Fis DIFUS, Hermosillo 83000, Sonora, Mexico

Barboza-Flores, M.:
 Univ Sonora UNISON, Dept Invest Fis DIFUS, Hermosillo 83000, Sonora, Mexico

Pedroza-Montero, M.:
 Univ Sonora UNISON, Dept Invest Fis DIFUS, Hermosillo 83000, Sonora, Mexico

Reyes-Leyva, J. R.:
 IMSS, Ctr Invest Biomed Oriente CIBIOR, HGZ 5, Puebla 42730, Mexico

Hernandez, J.:
 CIAD, Km 0-6 Carretera Victoria, Hermosillo 83304, Sonora, Mexico
ISSN: 22147853
Editorial
Elsevier Ltd, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, Reino Unido
Tipo de documento: Proceedings Paper
Volumen: 3 Número: 2
Páginas: 703-707
WOS Id: 000370378000101