Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
Por:
Imamura, Minako, Takahashi, Atsushi, Yamauchi, Toshimasa, Hara, Kazuo, Yasuda, Kazuki, Grarup, Niels, Zhao, Wei, Wang, Xu, Huerta-Chagoya, Alicia, Hu, Cheng, Moon, Sanghoon, Long, Jirong, Kwak, Soo Heon, Rasheed, Asif, Saxena, Richa, Ma, Ronald C. W., Okada, Yukinori, Iwata, Minoru, Hosoe, Jun, Shojima, Nobuhiro, Iwasaki, Minaka, Fujita, Hayato, Suzuki, Ken, Danesh, John, Jorgensen, Torben, Jorgensen, Marit E., Witte, Daniel R., Brandslund, Ivan, Christensen, Cramer, Hansen, Torben, Mercader, Josep M., Flannick, Jason, Moreno-Macias, Hortensia, Burtt, Noel P., Zhang, Rong, Kim, Young Jin, Zheng, Wei, Singh, Jai Rup, Tam, Claudia H. T., Hirose, Hiroshi, Maegawa, Hiroshi, Ito, Chikako, Kaku, Kohei, Watada, Hirotaka, Tanaka, Yasushi, Tobe, Kazuyuki, Kawamori, Ryuzo, Kubo, Michiaki, Cho, Yoon Shin, Chan, Juliana C. N., Sanghera, Dharambir, Kawamori, Ryuzo, Kubo, Michiaki, Cho, Yoon Shin, Chan, Juliana C. N., Sanghera, Dharambir, Frossard, Philippe, Park, Kyong Soo, Shu, Xiao-Ou, Kim, Bong-Jo, Florez, Jose C., Tusie-Luna, Teresa, Jia, Weiping, Tai, E. Shyong, Pedersen, Oluf, Saleheen, Danish, Maeda, Shiro, Kadowaki, Takashi
Publicada:
1 ene 2016
Resumen:
Genome-wide association studies (GWAS) have identified more than 80
susceptibility loci for type 2 diabetes (T2D), but most of its
heritability still remains to be elucidated. In this study, we conducted
a meta-analysis of GWAS for T2D in the Japanese population. Combined
data from discovery and subsequent validation analyses (23,399 T2D cases
and 31,722 controls) identify 7 new loci with genome-wide significance
(P<5 x 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972
near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near
MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci
with T2D is replicated in multi-ethnic populations other than Japanese
(up to 65,936 T2Ds and 158,030 controls, P<0.007). These results
indicate that expansion of single ethnic GWAS is still useful to
identify novel susceptibility loci to complex traits not only for
ethnicity-specific loci but also for common loci across different
ethnicities.
Filiaciones:
Imamura, Minako:
RIKEN Ctr Integrat Med Sci, Lab Endocrinol Metab & Kidney Dis, Yokohama, Kanagawa 2300045, Japan
Takahashi, Atsushi:
RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa 2300045, Japan
Natl Cerebral & Cardiovasc Ctr, Lab Omics Informat Omics Res Ctr, Suita, Osaka 5658565, Japan
Yamauchi, Toshimasa:
Univ Tokyo, Dept Diabet & Metab Dis, Grad Sch Med, Tokyo 1130033, Japan
Hara, Kazuo:
Univ Tokyo, Dept Diabet & Metab Dis, Grad Sch Med, Tokyo 1130033, Japan
Tokyo Med Univ, Dept Diabet Endocrinol Metab & Rheumatol, Tokyo 1600023, Japan
Yasuda, Kazuki:
Natl Ctr Global Hlth & Med, Dept Metab Disorder, Diabet Res Ctr, Res Inst, Tokyo 1628655, Japan
Grarup, Niels:
Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark
Zhao, Wei:
Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
Wang, Xu:
Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 138672, Singapore
Huerta-Chagoya, Alicia:
Univ Nacl Autonoma Mexico, Unidad Biologi Mol & Med Genom, Inst Invest Biomed, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City 14000, DF, Mexico
Hu, Cheng:
Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Diabet Inst, Dept Endocrinol & Metab,Shanghai Key Lab Diabet M, Shanghai 200233, Peoples R China
Moon, Sanghoon:
Ctr Genome Sci, Natl Inst Hlth, Div Struct & Funct Gen, Chungcheongbuk Do 28159, South Korea
Long, Jirong:
Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Sch Med, Nashville, TN 37203 USA
Kwak, Soo Heon:
Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea
Rasheed, Asif:
Ctr Non Communicable Dis, Karachi, Pakistan
Saxena, Richa:
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Ma, Ronald C. W.:
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Hong Kong, Peoples R China
Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China
Okada, Yukinori:
RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa 2300045, Japan
Tokyo Med & Dent Univ, Dept Human Genet & Dis Div, Grad Sch Med & Dent Sci, Tokyo 1138510, Japan
Iwata, Minoru:
Toyama Univ, Dept Internal Med 1, Toyama 9300194, Japan
Toyama Univ, Hlth Adm Ctr, Toyama 9300194, Japan
Hosoe, Jun:
Univ Tokyo, Dept Diabet & Metab Dis, Grad Sch Med, Tokyo 1130033, Japan
Shojima, Nobuhiro:
Univ Tokyo, Dept Diabet & Metab Dis, Grad Sch Med, Tokyo 1130033, Japan
Iwasaki, Minaka:
Univ Tokyo, Dept Diabet & Metab Dis, Grad Sch Med, Tokyo 1130033, Japan
Fujita, Hayato:
Univ Tokyo, Dept Diabet & Metab Dis, Grad Sch Med, Tokyo 1130033, Japan
Suzuki, Ken:
Univ Tokyo, Dept Diabet & Metab Dis, Grad Sch Med, Tokyo 1130033, Japan
Danesh, John:
Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England
Wellcome Trust Genome Campus Hinxton, Wellcome Trust Sanger Inst, Cambridge CB10 1RQ, England
Univ Cambridge, NIHR Blood & Transplant Res Unit Donor Hlth & Gen, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England
Jorgensen, Torben:
Capital Reg Denmark, Res Ctr Prevent & Hlth, DK-2600 Glostrup, Denmark
Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, DK-2200 Copenhagen, Denmark
Aalborg Univ, Fac Med, DK-9220 Aalborg, Denmark
Jorgensen, Marit E.:
Steno Diabet Ctr, DK-2820 Gentofte, Denmark
Witte, Daniel R.:
Aarhus Univ, Dept Publ Hlth, DK-8000 Aarhus, Denmark
Danish Diabet Acad, DK-5000 Odense, Denmark
Brandslund, Ivan:
Lillebaelt Hosp, Dept Clin Biochem, DK-7100 Vejle, Denmark
Univ Southern Denmark, Inst Reg Hlth Res, DK-5230 Odense, Denmark
Christensen, Cramer:
Lillebaelt Hosp, Dept Med, DK-7100 Vejle, Denmark
Hansen, Torben:
Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark
Mercader, Josep M.:
Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA
MIT, Cambridge, MA 02142 USA
Barcelona Supercomputing Ctr, Joint BSC CRG IRB Res Program Computat Biol, Barcelona 08034, Spain
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Massachusetts Gen Hosp, Diabet Res Ctr, Diabet Unit, Boston, MA 02114 USA
Flannick, Jason:
Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA
MIT, Cambridge, MA 02142 USA
Harvard Univ, Dept Mol Biol, Sch Med, Boston, MA 02115 USA
Moreno-Macias, Hortensia:
Univ Autonomas Metropolitana, Mexico City 09340, DF, Mexico
Burtt, Noel P.:
Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA
MIT, Cambridge, MA 02142 USA
Zhang, Rong:
Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Diabet Inst, Dept Endocrinol & Metab,Shanghai Key Lab Diabet M, Shanghai 200233, Peoples R China
Kim, Young Jin:
Ctr Genome Sci, Natl Inst Hlth, Div Struct & Funct Gen, Chungcheongbuk Do 28159, South Korea
Zheng, Wei:
Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Sch Med, Nashville, TN 37203 USA
Singh, Jai Rup:
Cent Univ Punjab, Bathinda 151001, Punjab, India
Tam, Claudia H. T.:
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
Hirose, Hiroshi:
Keio Univ, Ctr Hlth, Tokyo 1608582, Japan
Maegawa, Hiroshi:
Shiga Univ Med Sci, Dept Med, Otsu, Shiga 5202192, Japan
Ito, Chikako:
Grand Tower Med Court Life Care Clin, Hiroshima 7300012, Japan
Kaku, Kohei:
Kawasaki Med Univ, Dept Internal Med, Kurashiki, Okayama 7010192, Japan
Watada, Hirotaka:
Juntendo Univ, Dept Endocrinol & Metab, Grad Sch Med, Tokyo 1138421, Japan
Juntendo Univ, Sportol Ctr, Grad Sch Med, Tokyo 1130034, Japan
Tanaka, Yasushi:
St Marianna Univ, Div Endocrinol & Metab, Dept Internal Med, Sch Med, Kawasaki, Kanagawa 2168511, Japan
Tobe, Kazuyuki:
Toyama Univ, Dept Internal Med 1, Toyama 9300194, Japan
Kawamori, Ryuzo:
Juntendo Univ, Sportol Ctr, Grad Sch Med, Tokyo 1130034, Japan
Kubo, Michiaki:
RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan
Cho, Yoon Shin:
Hallym Univ, Dept Biomed Sci, Chunchon 24252, Gangwon Do, South Korea
Chan, Juliana C. N.:
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
Sanghera, Dharambir:
Univ Oklahoma, Dept Pediat, Hlth Sci Ctr, Oklahoma City, OK 73104 USA
Kawamori, Ryuzo:
Juntendo Univ, Sportol Ctr, Grad Sch Med, Tokyo 1130034, Japan
Kubo, Michiaki:
RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan
Cho, Yoon Shin:
Hallym Univ, Dept Biomed Sci, Chunchon 24252, Gangwon Do, South Korea
Chan, Juliana C. N.:
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
Sanghera, Dharambir:
Univ Oklahoma, Dept Pediat, Hlth Sci Ctr, Oklahoma City, OK 73104 USA
Frossard, Philippe:
Ctr Non Communicable Dis, Karachi, Pakistan
Park, Kyong Soo:
Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea
Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul 03080, South Korea
Seoul Natl Univ, Dept Mol Med & Biopharmaceut Sci, Grad Sch Convergence Sci & Technol, Seoul 03080, South Korea
Shu, Xiao-Ou:
Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Sch Med, Nashville, TN 37203 USA
Kim, Bong-Jo:
Ctr Genome Sci, Natl Inst Hlth, Div Struct & Funct Gen, Chungcheongbuk Do 28159, South Korea
Florez, Jose C.:
Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA
MIT, Cambridge, MA 02142 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Massachusetts Gen Hosp, Diabet Res Ctr, Diabet Unit, Boston, MA 02114 USA
Harvard Univ, Dept Med, Sch Med, Boston, MA 02115 USA
Tusie-Luna, Teresa:
Univ Nacl Autonoma Mexico, Unidad Biologi Mol & Med Genom, Inst Invest Biomed, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City 14000, DF, Mexico
Jia, Weiping:
Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Diabet Inst, Dept Endocrinol & Metab,Shanghai Key Lab Diabet M, Shanghai 200233, Peoples R China
Tai, E. Shyong:
Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 138672, Singapore
Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 119228, Singapore
Duke Natl Univ Singapore, Grad Sch, Singapore 169857, Singapore
Pedersen, Oluf:
Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark
Saleheen, Danish:
Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
Ctr Non Communicable Dis, Karachi, Pakistan
Maeda, Shiro:
RIKEN Ctr Integrat Med Sci, Lab Endocrinol Metab & Kidney Dis, Yokohama, Kanagawa 2300045, Japan
Univ Ryukyus, Grad Sch Med, Dept Adv Genom & Lab Med, Nishihara, Okinawa 9030215, Japan
Univ Ryukyus Hosp, Div Clin Lab & Blood Transfus, Nishihara, Okinawa 9030215, Japan
Kadowaki, Takashi:
Univ Tokyo, Dept Diabet & Metab Dis, Grad Sch Med, Tokyo 1130033, Japan
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